Ophthalmic formulations including selective alpha 1 antagonists
Ophthalmic formulations are provided. The ophthalmic formulations include one or more active agents that act to optimize pupil light reflex while minimizing, or effectively eliminating, any undesired eye redness in response to application thereof. The active agents include, for example, alpha 1 antagonists, such as alpha 1a selective antagonists.
1. A method of modulating pupil dilation, the method comprising: administering to an eye of an individual an ophthalmic formulation in an emulsified form comprising a sterile aqueous carrier including an ophthalmic artificial tear solution, and a therapeutically effective amount of an alpha 1 antagonist that selectively effects an iris alpha adrenergic receptor over a vascular alpha adrenergic receptor; and allowing the ophthalmic formulation to remain in contact with the eye for a period of time in a reduced light where a dilator muscle of the eye receives greater stimulation in absence of the ophthalmic formulation and eye redness is minimized, wherein the alpha 1 antagonist comprises a dihydroindole, and wherein the dihhydroindole is KMD-3213.
2. The method of claim 1 , wherein the ophthalmic formulation is administered in an amount so as to provide an optimized pupil diameter of about 6 mm or less.
3. The method of claim 2 , wherein the optimized pupil diameter ranges from about 3 mm to about 5 mm.
4. The method of claim 2 , wherein the optimized pupil diameter ranges from about 2.75 mm to about 4 mm.
5. The method of claim 1 , wherein the ophthalmic formulation does not effect a pupil diameter at about 2 mm or less in a bright light.
6. The method of claim 1 , wherein a pupil diameter is reduced by about 1 mm or more to optimize pupil diameter.
7. The method of claim 1 , wherein a pupil area is reduced by about 20% or more to optimize pupil diameter.
8. The method of claim 1 , wherein the ophthalmic formulation is administered in an amount so as to reduce an adverse visual effect.
9. The method of claim 8 , wherein the adverse visual effect is due to at least one of a perceived light scattering, a reduced contrast sensitivity and a reduced acuity.
10. The method of claim 9 , wherein the adverse visual effect is due to an imperfect aspheric peripheral corneal curvature.
11. The method of claim 9 , wherein the adverse visual effect is due to a higher order aberration of the eye selected from the group consisting of a coma, a secondary astigmatism, a spherical aberration, a trifoil, quadrafoil, and a tetrafoil.
12. The method of claim 9 , wherein the adverse visual effect is due to an uncorrected spherocylindrical correction contributed to by peripheral zones of a cornea.
13. A method of administering an ophthalmic formulation comprising a sterile aqueous carrier including an ophthalmic artificial tear solution to an eye of an individual comprising administering a therapeutically effective amount of an alpha 1 antaaonist within the ophthalmic formulation that selectively effects an iris alpha adrenergic receptor over a vascular alpha adrenergic receptor wherein the ophthalmic formulation optimizes a pupil diameter while effectively minimizing eye redness, wherein the alpha 1 antagonist comprises dihydroindole, and wherein the dihydroindole is KMD-3213.
14. The method of claim 13 , wherein the ophthalmic formulation further promotes conical absorption over vascular effect via a chemical modulation of a vascular tissue.
15. The method of claim 14 , wherein the chemical modulation includes a temporary shielding or binding to a conjunctiva of the eye.
16. The method of claim 14 , wherein the chemical modulation increases corneal absorption without effect on vascular absorption.
17. The method of claim 14 , wherein the chemical modulation increases corneal absorption while decreasing vascular absorption.
18. The method of claim 14 , wherein the chemical modulation occurs through exposure to one or more substances selected from the group consisting of a bioflavonoid, vitamin A, and substances derived from fruits and vegetables in order to reduce capillary permeability, including herbal extracts including aescin.
19. The method of claim 14 , wherein the chemical modulation occurs through use of one or more substances selected from the group consisting of demulcents, herbal extracts, horse chestnut extracts, and a substance containing mucilage.
20. The method of claim 13 , wherein a mucous membrane of the eye is protected from chemical irritants, to soothe the eye and/or to reduce redness, burning, stinging, or dryness by binding a protective layer to the mucous membrane of the eye and the conjunctiva.
21. The method of claim 13 , wherein a mucous membrane of the eye is protected from chemical irritants, to soothe the eye and/or to reduce redness, burning, stinging, or dryness by reducing a capillary permeability of the eye and increasing a venous tone by using bioflavonoids.
22. The method of claim 14 , wherein the chemical modulation occurs through a chemical modulator selected from the group consisting of an azone, a collagen corneal shield, a cyclodextrin including a charged cyclodextrin and a sulfated cyclodextrin, a bioadhesive polymer, a microsphere, a chitosan, a captisol, and derivatives thereof.
23. The method of claim 14 , wherein the chemical absorption is increased via one or more carrier particles selected from the group consisting of nanoparticles including liposomes and emulsions, dendrimers, and buckeyballs.
24. The method of claim 13 , wherein the pupil diameter is optimized to about 6 mm or less.
25. The method of claim 24 , wherein the pupil diameter is optimized to about 3.0 mm to about 5.0 mm in size.
26. The method of claim 13 , wherein the pupil diameter is optimized to about 2.75 mm to about 4.0 mm.
27. The method of claim 13 , wherein, the ophthalmic formulation does not effect pupil diameter at about 2 mm or less in a bright light.
28. The method of claim 24 , wherein the pupil diameter is reduced by about 1 mm or more to optimize pupil diameter.
29. The method of claim 24 , wherein the pupil diameter is optimized by reducing a pupil area by about 20%.
30. The method of claim 13 , wherein KMD-3213 acts as a sole active ingredient to optimize pupil diameter.
31. An ophthalmic formulation in an emulsified form for topical administration, the ophthalmic formulation comprising:
a sterile aqueous carrier including an ophthalmic artificial tear solution, and
a therapeutically effective amount of an alpha 1 antagonist that selectively effects an iris alpha adrenergic receptor over a vascular alpha adrenergic receptor for optimizing a pupil diameter in a reduced light while minimizing eye redness,
wherein the alpha 1 antagonist comprises a dihydroindole, and wherein the dihydroindole is KMD-3213.
32. The ophthalmic formulation of claim 31 , wherein the alpha 1 antagonist is selective for an iris dilator smooth muscle alpha adrenergic receptor.
33. The ophthalmic formulation of claim 32 , wherein the alpha 1 antagonist effectively reduces activity of the iris dilator smooth muscle.
34. The ophthalmic formulation of claim 33 , wherein the alpha 1 antagonist reduces activity of the iris dilator muscle effectively without constriction of an iris sphincter muscle.
35. The ophthalmic formulation of claim 31 , wherein the alpha 1 antagonist is selective for an alpha 1a adrenergic receptor over an alpha 1b adrenergic receptor.
36. The ophthalmic formulation of claim 31 , wherein the ophthalmic formulation is in an eye dropper.
37. The ophthalmic formulation of claim 31 , wherein the ophthalmic artificial tear solution includes hydroxypropyl methylcellulose in an amount of about 0.2% to 1.5% by weight of the ophthalmic artificial tear solution.
38. The ophthalmic formulation of claim 31 , wherein the pupil diameter is 6 mm or greater.
39. The ophthalmic formulation of claim 31 , wherein the pupil diameter is optimized to 6 mm or less.
40. The ophthalmic formulation of claim 31 , wherein the pupil diameter is optimized in the reduced light without eye redness.
41. The method of claim 1 , wherein the ophthalmic formulation is administered to the eye having a pupil diameter of 6 mm or greater.
42. The method. of claim 1 , wherein the ophthalmic formulation is allowed to remain in contact with the eye for the period of time in the reduced light where the dilator muscle of the eye receives greater stimulation in absence of the ophthalmic formulation and without eye redness.
43. The method of claim 13 , wherein the ophthalmic formulation optimizes the pupil diameter of 6 mm or greater.
44. The method of claim 13 , wherein the ophthalmic formulation optimizes the pupil diameter without eye redness.