IP Library Granted Patent US 8,894,969
Granted Patent B2
US 8,894,969 · App. 10/554,743 · Granted Nov 25, 2014

Method and device for radiotherapy

Inventors: Itzhak Kelson (Tel Aviv, IL); Lior Arazi (Tel Aviv, IL)
Assignee: Althera Medical Ltd.
A61N5/1007A61K9/0019A61N5/1027A61N5/1001A61K51/1282A61K2121/00
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Quick Facts
Patent No.
US 8,894,969
App. No.
10/554,743
Granted
Nov 25, 2014
Kind
B2
Abstract

A radiotherapy method, comprising positioning a predetermined amount of a radionuclide selected from the group consisting of Radium-223, Radium-224, Radon-219 and Radon-220, in proximity to and/or within a tumor of a subject, for a predetermined time period. The predetermined amount and the predetermined time period are selected sufficient for the radionuclide to administering a predetermined therapeutic dose of decay chain nuclei and alpha particles into the tumor.

Claims (27)

1. A radiotherapy device, comprising:

a removable probe, adapted for being at least partially introduced into a body of a subject and comprising at least one object selected from the group consisting of a needle, a tip of an endoscope, a tip of a laparoscope and a tip of an imaging device; and

a radionuclide selected from the group consisting of Radium-223 and Radium-224, said radionuclide being retainably embedded on or beneath a surface of said object, said embedding ensuring that said radionuclide remains in said probe while a therapeutic dose of decay chain nuclei and alpha particles of said radionuclide is emitted outside said surface;

said probe being coated by a protective coat, wherein a thickness and a material of said protective coat is selected so as not to prevent said emission of said decay chain nuclei and said alpha particles.

2. The device of claim 1 , further comprising a detector, capable of detecting said radionuclide, said decay chain nuclei and said alpha particles.

3. The device of claim 1 , wherein said object comprises an inner elongated member and an outer tubular member having a mouth section configured for receiving said inner elongated member, said inner elongated member being movable within said outer tubular member and having a distal end and a proximal end, whereby said radionuclide is on or beneath a surface of said distal end.

4. The device of claim 1 , wherein said probe is capable of releasing at least a portion of said radionuclide therefrom, thereby allowing distribution of said radionuclide prior to said emission of said decay chain nuclei and alpha particles.

5. The device of claim 4 , wherein said release of said at least a portion of said radionuclide is by body fluids.

6. A radiotherapy device, comprising:

an uncoated removable probe, adapted for being at least partially introduced into a body of a subject and comprising at least one object selected from the group consisting of a needle, a tip of an endoscope, a tip of a laparoscope and a tip of an imaging device; and

a radionuclide selected from the group consisting of Radium-223 and Radium-224, said radionuclide being embedded on or beneath a surface of said object, wherein said radionuclide remains in said probe while a therapeutic dose of decay chain nuclei and alpha particles of said radionuclide is emitted outside said surface.

7. The device of claim 6 , wherein said object comprises an inner elongated member and an outer tubular member having a mouth section configured for receiving said inner elongated member, said inner elongated member being movable within said outer tubular member and having a distal end and a proximal end, whereby said radionuclide is on or beneath a surface of said distal end.

8. The device of claim 6 , wherein said probe is capable of releasing at least a portion of said radionuclide therefrom, thereby allowing distribution of said radionuclide prior to said emission of said decay chain nuclei and alpha particles.

9. The device of claim 8 , wherein said release of said at least a portion of said radionuclide is by body fluids.

10. The device of claim 1 , wherein said radionuclide is implanted on or beneath said surface.

11. A radiotherapy device, comprising:

a removable probe, adapted for being at least partially introduced into a body of a subject, said removable probe located at a distal end of an inner elongated member, said inner tubular member associated with an outer tubular member having a mouth section configured for receiving said inner elongated member, said inner elongated member being movable within said outer tubular member and having a distal end and a proximal end; and

a radionuclide selected from the group consisting of Radium-223 and Radium-224, said radionuclide being retainably embedded on or beneath a surface of said distal end, wherein a therapeutic dose of decay chain nuclei and alpha particles of said radionuclide is emitted outside said surface;

said probe being coated by a protective coat, wherein a thickness and a material of said protective coat is selected so as not to prevent said emission of said decay chain nuclei and said alpha particles.

12. A radiotherapy device, comprising:

an uncoated removable probe, adapted for being at least partially introduced into a body of a subject, and located at a distal end of an inner elongated member, said inner elongated member associated with an outer tubular member having a mouth section configured for receiving said inner elongated member, said inner elongated member being movable within said outer tubular member and having a distal end and a proximal end; and

a radionuclide selected from the group consisting of Radium-223 and Radium-224, said radionuclide being retainably embedded on or beneath a surface of said distal end, wherein a therapeutic dose of decay chain nuclei and alpha particles of said radionuclide is emitted outside said surface.

13. The device of claim 11 , wherein said outer tubular member comprises at least one window, for allowing protrusion of said distal end of said inner elongated member therethrough.

14. A radiotherapy device, comprising:

a removable probe, adapted for being at least partially introduced into a body of a subject and comprising at least one object selected from the group consisting of a needle, a tip of an endoscope, a tip of a laparoscope and a tip of an imaging device and an injectable bead; and

a radionuclide selected from the group consisting of Radium-223 and Radium-224, said radionuclide being retainably embedded on or beneath a surface of said bead, said embedding ensuring that said radionuclide remains in said probe while a therapeutic dose of decay chain nuclei and alpha particles of said radionuclide is emitted outside said surface;

said injectable bead being coated by a protective coat, wherein a thickness and a material of said protective coat is selected so as not to prevent said emission of said decay chain nuclei and said alpha particles.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 8, 2016
From: ALTHERA MEDICAL LTD.
To: ALPHA TAU MEDICAL LTD.
Reel/Frame 038839/0876 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 5, 2014
From: RAMOT AT TEL-AVIV UNIVERSITY LTD.
To: ALTHERA MEDICAL LTD.
Reel/Frame 034103/0851 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 26, 2005
From: KELSON, ITZHAK; ARAZI, LIOR
To: RAMOT AT TEL AVIV UNIVERSITY LTD.
Reel/Frame 018085/0542 →
Continuity (2)
Provisional Application 60466408 · Apr 30, 2003
Related Publication 20070041900A1 · Feb 22, 2007