Granted Patent
B2
US 8,901,151 · App. 13/893,382 · Granted Dec 2, 2014
Preparation and therapeutic applications of (2S, 3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]OCT-3-yl)-3,5-difluorobenzamide
Inventors:
Merouane Bencherif (Winston-Salem, NC); Nikolai Fedorov (Winston-Salem, NC); Terry Hauser (Winston-Salem, NC); Kristen Jordan (Clemmons, NC); Sharon Rae Letchworth (Kernersville, NC); Anatoly Mazurov (Greensboro, NC); Julio A. Munoz (Walnut Cove, NC); Jason Speake (Winston-Salem, NC); Daniel Yohannes (Winston-Salem, NC)
Assignee:
Targacept, Inc.
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Abstract
The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
Claims (1)
1. A method for improving memory, comprising administering to a patient in need thereof an effective amount of a compound (2S,3R)—N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide (Formula I) or a pharmaceutically acceptable salt thereof
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 9, 2016
From: CATALYST BIOSCIENCES, INC.
To: ATTENUA, INC.
Reel/Frame 039688/0771 →
CHANGE OF NAME
Recorded Aug 11, 2016
From: TARGACEPT , INC.
To: CATALYST BIOSCIENCES, INC.
Reel/Frame 039646/0595 →
Continuity (3)
Continuation
12740970
Provisional Application
61147260
· Jan 26, 2009