Biofilm inhibiting composition
Polysaccharide-containing extracts isolated from a host cell containing nucleotide sequences encoding genes pamA, pamB and pamC, wherein the extract is capable of inhibiting biofilm formation produced by gram-negative bacteria, gram-positive bacteria and fungi, and methods to inhibit biofilm formation or remove biofilms that have already formed.
1. A composition comprising a linear polysaccharide comprising →3)-β-D-Galf-(1→6)-β-D-Galf-(1→subunits.
2. A pharmaceutical composition comprising the composition of claim 1 and a pharmaceutically acceptable carrier.
3. The pharmaceutical composition of claim 2 , wherein said pharmaceutical composition is in oral administration form.
4. The pharmaceutical composition of claim 3 , wherein said pharmaceutical composition is a lozenge, a mouth wash, or a piece of chewing gum.
5. The pharmaceutical composition of claim 2 , wherein said composition is in topical administration form.
6. The pharmaceutical composition of claim 5 , wherein said composition is an ointment, a cream or a lotion.