Quinazoline derivatives for the treatment of viral infections and further diseases
This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.
1. A compound of formula (I)
or a pharmaceutically acceptable salt wherein
R 1 is one of the following:
R 2 is hydrogen, halogen, hydroxyl, amine, C 1-7 alkyl, C 1-7 alkylamino, C 1-6 alkoxy, or (C 1-4 )alkoxy-(C 1-4 )alkyl,
R 3 is hydrogen, halogen, hydroxyl, amine, C 1-7 alkyl, C 1-7 alkenyl, C 1-7 alkynyl, C 1-7 alkylamino, C 1-6 alkoxy, or (C 1-4 )alkoxy-(C 1-4 )alkyl,
R 4 is hydrogen, halogen, hydroxyl, amine, C 1-7 alkyl, C 1-7 alkylamino, C 1-6 alkoxy, or (C 1-4 )alkoxy-(C 1-4 )alkyl, and
R 5 is hydrogen, fluorine, chlorine or methyl with the proviso that
R 2 , R 3 , R 4 , and R 5 cannot all be H.
2. A compound of formula (I) according to claim 1 wherein R 5 is hydrogen or fluorine.
3. A compound of claim 1 selected from the group consisting of
and a pharmaceutically acceptable salt thereof.
4. A compound of claim 1 having the structure:
or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients, diluents or carriers.