Pyrimidinones as PI3K inhibitors
The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
1. A compound, which is (S)-7-(1-(9H-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one; or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , which is (S)-7-(1-(9H-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one.
3. A compound, which is 6-(3-fluorophenyl)-3-methyl-7-[1-(9H-purin-6-ylamino)ethyl]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, or a pharmaceutically acceptable salt thereof.
4. The compound of claim 3 , which is 6-(3-fluorophenyl)-3-methyl-7-[1-(9H-purin-6-ylamino)ethyl]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one.
5. A composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
6. A composition comprising a compound according to claim 3 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
7. A composition comprising a compound according to claim 2 and at least one pharmaceutically acceptable carrier.
8. A composition comprising a compound according to claim 4 and at least one pharmaceutically acceptable carrier.
9. A method of treating arthritis in a patient, comprising administering to said patient a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.
10. A method of treating arthritis in a patient, comprising administering to said patient a therapeutically effect amount of a compound of claim 3 , or a pharmaceutically acceptable salt thereof.
11. A method of treating arthritis in a patient, comprising administering to said patient a therapeutically effective amount of a compound of claim 2 .
12. A method of treating arthritis in a patient, comprising administering to said patient a therapeutically effective amount of a compound of claim 4 .
13. A method of treating rheumatoid arthritis in a patient, comprising administering to said patient a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.
14. A method of treating rheumatoid arthritis in a patient, comprising administering to said patient a therapeutically effect amount of a compound of claim 3 , or a pharmaceutically acceptable salt thereof.
15. A method of treating rheumatoid arthritis in a patient, comprising administering to said patient a therapeutically effective amount of a compound of claim 2 .
16. A method of treating rheumatoid arthritis in a patient, comprising administering to said patient a therapeutically effective amount of a compound of claim 4 .