Granted Patent
B2
US 8,952,049 · App. 13/781,392 · Granted Feb 10, 2015
Modulators of ATP-binding cassette transporters
Inventors:
Sara Sabina Hadida Ruah (La Jolla, CA); Peter Diederik Jan Grootenhuis (San Diego, CA); Fredrick F. Van Goor (San Diego, CA); Jinglan Zhou (San Diego, CA); Brian Richard Bear (Oceanside, CA); Mark Thomas Miller (San Diego, CA); Jason McCartney (Cardiff-by-the-Sea, CA); Mehdi Michel Djamel Numa (San Diego, CA)
Assignee:
Vertex Pharmaceuticals Incorporated
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Abstract
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Claims (4)
1. A method of treating male infertility or pancreatic insufficiency in a patient, comprising the step of administering to said patient a compound which is:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the patient has male infertility.
3. The method of claim 1 , wherein the patient has pancreatic insufficiency.
Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 13, 2018
From: HADIDA RUAH, SARA S.; GROOTENHUIS, PETER D.J.; VAN GOOR, FREDRICK F.; ZHOU, JINGLAN; BEAR, BRIAN; MILLER, MARK T.; MCCARTNEY, JASON; NUMA, MEHDI MICHEL DJAMEL
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 045532/0521 →
RELEASE OF SECURITY INTEREST
Recorded Oct 14, 2016
From: MACQUARIE US TRADING LLC
To: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 040357/0001 →
ASSIGNEE CHANGE OF ADDRESS
Recorded Feb 11, 2016
From: VERTEX PHARMACEUTICALS INCORPORATED
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 037781/0332 →
SECURITY INTEREST
Recorded Jul 10, 2014
From: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
To: MACQUARIE US TRADING LLC
Reel/Frame 033292/0311 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 6, 2013
From: HADIDA-RUAH, SARA S.; GROOTENHUIS, PETER D.J.; VAN GOOR, FREDRICK; ZHOU, JINGLAN; BEAR, BRIAN; MILLER, MARK T.; MCCARTNEY, JASON; NUMA, MEHDI MICHEL DJMEL
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 031551/0754 →