Antibodies to human programmed death receptor PD-1
Antibodies which block binding of hPD-1 to hPD-L1 or hPD-L2 and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune cell through the PD-1 pathway is also disclosed.
1. An isolated antibody or antibody fragment which binds to human programmed death receptor-1 (PD-1), comprising
a. light chain CDRs of SEQ ID NOs: 9, 10 and 11; and
b. heavy chain CDRs of SEQ ID NOs: 12, 13 and 14;
wherein said antibody or antibody fragment blocks binding of human PD-L1 and human PD-L2 to human PD-1.
2. The antibody or antibody fragment of claim 1 , comprising:
a. a heavy chain variable region comprising SEQ ID NO: 5; and
b. a light chain variable region comprising SEQ ID NO: 6.
3. The antibody or antibody fragment of claim 2 , further comprising a heavy chain constant region comprising a γ4 or γ1 human heavy chain constant region.