IP Library › Granted Patent US 8,962,029
Granted Patent B2
US 8,962,029 · App. 14/015,015 · Granted Feb 24, 2015

Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications

Inventors: Mark H. Schoenfisch (Chapel Hill, NC); Jae Ho Shin (Chapel Hill, NC); Nathan Stasko (Chapel Hill, NC)
Assignee: The University of North Carolina at Chapel Hill
C07F7/10A61K9/14A61K9/167A61K9/5115A61K41/0042A61K47/48192A61K47/48861A61K47/48884B82Y5/00B82Y10/00B82Y30/00C07F7/18
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Quick Facts
Patent No.
US 8,962,029
App. No.
14/015,015
Granted
Feb 24, 2015
Kind
B2
Abstract

The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.

Claims (4)

1. A nitric oxide-releasing particle comprising:

a co-condensed silica network comprising aminoethylaminopropyl trimethoxysilane (AEAP3) and tetraethyl orthosilicate (TEOS), wherein the AEAP3 is distributed throughout the nitric oxide-releasing particle, and wherein the AEAP3 comprises N-diazeniumdiolate functionalized AEAP3.

2. The nitric oxide-releasing particle of claim 1 , wherein the AEAP3 is present in a mol % of 1% to 90%.

3. The nitric oxide-releasing particle of claim 1 or claim 2 , wherein the AEAP3 is present in a mol % of about 50%.

Assignments (4)
CORRECTION BY DECLARATION ERRONEOUSLY FILED AGAINST REEL 066350/FRAME 0942 Recorded Nov 12, 2024
From: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
To: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Reel/Frame 069386/0419 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 18, 2024
From: NOVAN, INC.
To: LNHC, INC.
Reel/Frame 066350/0942 →
CONFIRMATORY LICENSE Recorded Oct 28, 2013
From: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031498/0923 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 5, 2013
From: SCHOENFISCH, MARK H.; SHIN, JAE HO; STASKO, NATHAN
To: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Reel/Frame 031141/0747 →
Continuity (4)
Continuation 13157036 · Jun 9, 2011
Continuation 11887041
Provisional Application 60685578 · May 27, 2005
Related Publication 20140005426A1 · Jan 2, 2014