IP Library Granted Patent US 8,962,831
Granted Patent B2
US 8,962,831 · App. 14/117,933 · Granted Feb 24, 2015

Tyrosine kinase inhibitors

Inventor: David Michael Goldstein (Redwood City, CA)
Assignee: Principia Biopharma Inc.
C07D487/04A61K31/519A61K31/5377A61K45/06
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Quick Facts
Patent No.
US 8,962,831
App. No.
14/117,933
Granted
Feb 24, 2015
Kind
B2
Abstract

The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.

Claims (3)

1. 3-(2-Fluoro-4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine having the structure

or a salt thereof.

2. 3-(2-Fluoro-4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine having the structure

Assignments (3)
ASSIGNEE CHANGE OF ADDRESS Recorded Sep 16, 2025
From: PRINCIPIA BIOPHARMA INC.
To: PRINCIPIA BIOPHARMA INC.
Reel/Frame 072881/0270 →
ASSIGNEE CHANGE OF ADDRESS Recorded Mar 22, 2019
From: PRINCIPIA BIOPHARMA INC.
To: PRINCIPIA BIOPHARMA INC.
Reel/Frame 048675/0297 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 12, 2014
From: GOLDSTEIN, DAVID MICHAEL; BRAMELD, KENNETH ALBERT
To: PRINCIPIA BIOPHARMA INC.
Reel/Frame 034159/0622 →
Continuity (5)
Provisional Application 61486944 · May 17, 2011
Provisional Application 61514892 · Aug 3, 2011
Provisional Application 61556336 · Nov 7, 2011
Provisional Application 61618152 · Mar 30, 2012
Related Publication 20140094459A1 · Apr 3, 2014