IP Library Granted Patent US 8,969,321
Granted Patent B2
US 8,969,321 · App. 14/087,677 · Granted Mar 3, 2015

Medical and nutritional applications of highly refined cellulose

Inventors: Paul Bradley Addis (Cumberland, WI); Rongsheng Roger Ruan (Arden Hills, MN); Joseph M. Keenan (Edina, MN); Daniela Geleva (Minneapolis, MN)
Assignee: Regents of the University of Minnesota
A61K31/717A23L1/0534A23L1/3082A23V2002/00A61K31/715Y10S514/866
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Quick Facts
Patent No.
US 8,969,321
App. No.
14/087,677
Granted
Mar 3, 2015
Kind
B2
Abstract

The present invention provides a method for using processed cellulose. Preferably, the processed cellulose is a highly refined cellulose (HRC). The HRC is useful in a number of medical and nutritional applications. These medical and nutritional applications can include, but are not limited to, administering effective amounts of the HRC for lowering values of risk factor measurements for such diseases as arteriosclerotic cardiovascular disease and diabetes. Treatment of other diseases and conditions with the HRC is also possible.

Claims (18)

1. A method, comprising:

providing an effective amount of an HRC, wherein ingesting the HRC and a nutritional source is effective to cause an acute decrease in the production of cholecystokinin in a mammal compared to the mammal ingesting the nutritional source, the HRC being substantially indigestible and comprising a water retention capacity of greater than about 10 grams of water per gram of dry HRC.

2. The method of claim 1 , wherein the acute decrease in the production of cholecystokinin in the mammal occurs no less than about twenty minutes after ingesting the effective amount of the HRC.

3. A method, comprising:

providing an effective amount of an HRC, wherein ingesting the HRC is effective to change at least one risk factor value for arteriosclerotic cardiovascular disease in a mammal, the HRC being substantially indigestible and comprising a water retention capacity of greater than about 10 grams of water per gram of dry HRC.

4. The method of claim 3 , wherein the HRC comprises no less than about 0.1 percent lignin by dry weight of HRC.

5. The method of claim 3 , wherein providing the effective amount of the HRC comprises providing at least about 5 grams within about a 24 hour interval to a mammal.

6. The method of claim 3 , wherein providing further comprises providing the effective amount postprandially to the mammal.

7. The method of claim 3 , wherein changing at least one risk factor value comprises decreasing blood pressure in the mammal.

8. The method of claim 3 , wherein changing at least one risk factor value comprises decreasing serum lipids in blood of the mammal.

9. The method of claim 8 , wherein decreasing serum lipids in blood comprises decreasing total cholesterol of the mammal.

10. The method of claim 8 , wherein decreasing serum lipids in blood comprises decreasing HDL-cholesterol of the mammal.

11. The method of claim 8 , wherein decreasing serum lipids in blood comprises decreasing LDL-cholesterol of the mammal.

12. The method of claim 8 , wherein decreasing serum lipids in blood comprises decreasing triglycerides of the mammal.

13. A method, comprising:

providing an effective amount of an HRC, wherein ingesting the HRC is effective to decrease serum lipids in blood of a mammal, the HRC being substantially indigestible and comprising a water retention capacity of greater than about 10 grams of water per gram of dry HRC.

14. A method, comprising:

providing an effective amount of an HRC, wherein ingesting the HRC is effective to decrease blood pressure in a mammal, the HRC being substantially indigestible and comprising a water retention capacity of greater than about 10 grams of water per gram of HRC.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 4, 2014
From: RUAN, RONGSHEN ROGER; ADDIS, PAUL B.
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 033665/0537 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 19, 2014
From: ADDIS, PAUL BRADLEY; RUAN, RONGSHENG ROGER; KEENAN, JOSEPH M.; GELEVA, DANIELA
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 033562/0672 →
CONFIRMATORY LICENSE Recorded Dec 18, 2013
From: REGENTS OF THE UNIVERSITY OF MINNESOTA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031837/0203 →
Continuity (4)
Continuation 13216793 · Aug 24, 2011
Division 10270475 · Oct 11, 2002
Provisional Application 60329255 · Oct 12, 2001
Related Publication 20140080786A1 · Mar 20, 2014