Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
The present invention provides formulations which may comprise macrocyclic lactones and at least one spirodioxepinoindole derivative or a spirooxepinoindole derivative for combating parasites in birds and mammals. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
1. A composition for the treatment of parasite infestation or infection in a ruminant animal which comprises:
(a) a pharmaceutically effective amount of at least one macrocyclic lactone derivative wherein the macrocyclic lactone derivative is ivermectin, doramectin, eprimomectin or moxidectin;
(b) a pharmaceutically effective amount of at least one paraherquamide or macfortine;
(c) a further anthelmintic agent selected from praziquantel, pyrantel, and morantel; and
(d) a pharmaceutically acceptable carrier.
2. The composition according to claim 1 , wherein the composition comprises a deoxyparaherquamide.
3. The composition according to claim 1 , which further comprises at least one additional macrocyclic lactone compound.
4. A method for the treatment of a parasitic infestation or infection in a ruminant animal which comprises administering a pharmaceutically effective amount of the composition of claim 1 to the ruminant animal.
5. The method of claim 4 , wherein the ruminant animal is a bovine.
6. The composition of claim 1 , wherein the composition is in the form of a paste formulation, an oral drench formulation, a capsule formulation, a chewable formulation, a sustained-release tablet, or a premix formulation.
7. The composition of claim 1 , wherein the composition is in the form of a sustained-release capsule for insertion in the rumen of a ruminant animal.
8. The composition according to claim 1 , wherein the macrocyclic lactone derivative is doramectin.
9. The composition according to claim 1 , wherein the macrocyclic lactone derivative is moxidectin.
10. The composition according to claim 1 , wherein the macrocyclic lactone derivative is ivermectin or eprinomectin.
11. The composition according to claim 3 , wherein the at least one additional macrocyclic lactone compound is eprinomectin and the further anthelmintic agent is praziquantel.
12. A composition for the treatment of parasite infestation or infection in a ruminant animal, the composition comprising:
(a) a pharmaceutically effective amount of a milbemycin selected from the group consisting of milbemectin, milbemycin D, nemadectin, and combinations thereof;
(b) a pharmaceutically effective amount of at least one spirodioxepinoindole derivative or a spirooxepinoindole derivative;
(c) a further anthelmintic agent selected from praziquantel, pyrantel, and morantel; and
(d) a pharmaceutically acceptable carrier.
13. The composition according to claim 12 , wherein the spirodioxepinoindole derivative is a paraherquamide.
14. The composition according to claim 12 , wherein the spirodioxepinoindole derivative is a deoxyparaherquamide.
15. The composition according to claim 12 , wherein the spirodioxepinoindole derivative is a macfortine.
16. The composition according to claim 12 , which further comprises at least one additional macrocyclic lactone compound.
17. The composition according to claim 16 , wherein the at least one additional macrocyclic lactone compound is eprinomectin and the further anthelmintic agent is praziquantel.
18. The composition of claim 12 , wherein the composition is in the form of a paste formulation, an oral drench formulation, a capsule formulation, a chewable formulation, a sustained-release tablet, or a premix formulation.
19. The composition of claim 12 , wherein the composition is in the form of a sustained-release capsule for insertion in the rumen of a ruminant animal.