Granted Patent
B2
US 8,992,902 · App. 14/283,788 · Granted Mar 31, 2015
N-maleimidyl polymer derivatives
Assignee:
Nektar Therapeutics
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Abstract
The invention is directed to multi-functional N-maleimidyl polymer derivatives comprising a water soluble and non-peptidic polymer backbone having a terminal carbon, such as a poly(alkylene glycol), the terminal carbon of the polymer backbone being directly bonded to the nitrogen atom of a N-maleimidyl moiety without a linking group therebetween. The invention also provides two methods of preparing such linkerless N-maleimidyl polymer derivatives.
Claims (4)
1. A multi-functional N-maleimidyl polymer derivative having the formula:
wherein:
X is amine; and
n is about 20 to about 4000.
Assignments (4)
RELEASE OF SECURITY INTEREST
Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 33105, FRAME 0898
Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036855/0524 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS
Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
SECURITY INTEREST
Recorded Jun 9, 2014
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 033105/0898 →
Continuity (6)
Provisional Application
60183833
· Feb 22, 2000