Carbonate prodrugs and methods of using the same
View Patent ↗The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety. The prodrugs may provide improved physicochemical properties over the parent drug. Also provided are methods of treating a disease or condition that is responsive to the parent drug using the carbonate prodrugs, as well as kits and unit dosages.
1. A method of treating a disease or condition that is responsive to acetaminophen, comprising administering to an individual an effective amount of the prodrug:
or a pharmaceutically acceptable salt thereof or solvate of the foregoing.
2. The method according to claim 1 , wherein disease or condition is selected from the group consisting of pain, fever, inflammation, ischemic injury, and neuronal injury.
3. The method according to claim 1 , wherein the prodrug is administered parenterally.
4. The method according to claim 3 , wherein the prodrug is administered intravenously.
5. The method according to claim 3 , wherein the prodrug is administered intramuscularly.
6. The method according to claim 3 , wherein the prodrug is administered subcutaneously.
7. The method according to claim 1 , wherein the dosage of the prodrug is about 300 mg to about 2.6 g.
8. The method according to claim 7 , wherein the dosage of the prodrug is about 1.3 g to about 1.9 g.
9. The method according to claim 7 , wherein the volume of the dosage is about 1 mL to about 25 mL.
10. The method according to claim 9 , wherein the volume of the dosage is about 10 mL to about 20 mL.
11. The method according to claim 9 , wherein the volume of the dosage is about 1 mL to about 10 mL.
12. The method according to claim 9 , wherein the volume of the dosage is about 5 mL to about 10 mL.