Modulators of ATP-binding cassette transporters

Inventors: Sara S. Hadida Ruah (La Jolla, CA); Matthew Hamilton (Hackettstown, NJ); Mark Miller (San Diego, CA); Peter D. J. Grootenhuis (San Diego, CA); Brian Bear (Oceanside, CA); Jason McCartney (Cardiff by the Sea, CA); Jinglan Zhou (San Diego, CA)

Assignee: Vertex Pharmaceuticals Incorporated

C07D405/12 A61K31/443 A61K45/06 A61K31/444 A61K31/4545 A61K31/4709 A61K31/496 A61K31/497 A61K31/501 A61K31/506 A61K31/5377 C07D405/14

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Quick Facts

Patent No.: US 8,993,600
App. No.: 12/114,935
Granted: Mar 31, 2015
Kind: B2

External Links

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Abstract

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Claims (4)

1. A pharmaceutical composition comprising:

(i) an effective amount of the compound:

or a pharmaceutically acceptable salt thereof; and

(ii) a pharmaceutically acceptable carrier.

Assignments (5)

RELEASE OF SECURITY INTEREST Recorded Oct 14, 2016

From: MACQUARIE US TRADING LLC

To: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC

Reel/Frame 040357/0001 →

ASSIGNEE CHANGE OF ADDRESS Recorded Feb 3, 2016

From: VERTEX PHARMACEUTICALS INCORPORATED