IP Library › Granted Patent US 9,012,425
Granted Patent B2
US 9,012,425 · App. 14/125,063 · Granted Apr 21, 2015

Methods for the treatment of Leber congenital amaurosis

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Quick Facts
Patent No.
US 9,012,425
App. No.
14/125,063
Granted
Apr 21, 2015
Kind
B2
Abstract

The present invention relates to a method for treating a Leber congenital amaurosis in a patient harboring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c.2291+1655 A>G CEP290 mRNA.

Claims (1)

1. A method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene comprising administering to the patient an effective amount of an antisense oligonucleotide which is SEQ ID NO:2 (ESE(+50+70)).

Assignments (6)
CHANGE OF NAME Recorded Mar 25, 2022
From: UNIVERSITÉ DE PARIS
To: UNIVERSITÉ PARIS CITÉ
Reel/Frame 059504/0225 →
MERGER Recorded Jul 22, 2021
From: UNIVERSITE DE PARIS DESCARTES
To: UNIVERSITE DE PARIS
Reel/Frame 056958/0603 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 26, 2018
From: UNIVERSITÉ D'EVRY VAL D'ESSONNE
To: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
Reel/Frame 047851/0278 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 12, 2015
From: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); GENETHON
To: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); GENETHON; UNIVERSITE PARIS DESCARTES; ENSCP - CHIMIE PARIS TECH - ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS; UNIVERSITE D'EVRY-VAL-D'ESSONNE; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
Reel/Frame 034948/0935 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 10, 2014
From: MUNNICH, M. ARNOLD
To: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE); GENETHON
Reel/Frame 034446/0914 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 6, 2014
From: ROZET, JEAN-MICHEL; KICHLER, ANTOINE; PERRAULT, ISABELLE; KAPLAN, JOSSELINE; GERARD, XAVIER; SCHERMAN, DANIEL
To: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE); GENETHON
Reel/Frame 032161/0652 →