Apparatus and methods for treating pulmonary hypertension
A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension.
1. A method of performing a procedure to destroy nerve fibers of a nerve innervating a pulmonary artery to treat pulmonary hypertension in a patient, the method comprising:
advancing a distal portion of a therapy delivery catheter to a target location in the pulmonary artery of the patient;
changing a shape of the distal portion of the catheter from a first configuration to a second configuration to cause the distal portion to contact an inner wall of the pulmonary artery at the target location;
delivering a therapy from at least one therapy delivery member disposed along the distal portion of the catheter to destroy the nerve fibers along a length of the nerve to treat the pulmonary hypertension in the patient; and
removing the catheter from the pulmonary artery and from the patient at the end of the procedure.
2. A method as in claim 1 , further comprising, before removing the catheter, changing the shape of the distal portion from the second configuration to the first configuration.
3. A method as in claim 1 , wherein the nerve comprises a sympathetic nerve.
4. A method as in claim 1 , wherein changing the shape of the distal portion from the first configuration to the second configuration comprises inflating an inflatable balloon.
5. A method as in claim 1 , wherein changing the shape of the distal portion from the first configuration to the second configuration comprises releasing a shape-memory portion of the catheter from a constraint to allow it to assume a default configuration.
6. A method as in claim 1 , wherein the at least one therapy delivery member comprises at least one energy delivery member, and wherein delivering the therapy comprises delivering a form of energy selected from the group consisting of radiofrequency, ultrasound, microwave, light, heat, cold, radiation, phototherapy, magnetic, electrical, electromagnetic, cryotherapy, plasma, mechanical, chemical, kinetic, potential, nuclear, elastic and hydrodynamic energy.
7. A method as in claim 1 , wherein the at least one therapy delivery member comprises at least one substance delivery member, and wherein delivering the therapy comprises delivering at least one substance via the at least one substance delivery member.
8. A method as in claim 1 , wherein delivering the therapy from the at least one therapy delivery member comprises delivering the therapy from multiple therapy delivery members disposed along a length of the distal portion and around a circumference of the distal portion.
9. A method as in claim 1 , wherein, after the catheter is removed, no implant is left behind in the pulmonary artery.
10. A method of performing a procedure to treat pulmonary hypertension by reducing pulmonary vascular resistance in a patient, the method comprising:
advancing an energy delivery portion of a catheter to a target location in a pulmonary artery;
changing a shape of the energy delivery portion from a first configuration to a second configuration to contact an inner wall of the pulmonary artery at the target location with multiple, circumferential energy delivery members disposed at separated locations along a length of the energy delivery portion;
delivering energy from the energy delivery members to destroy nerve fibers of a sympathetic nerve that innervates the pulmonary artery to reduce the pulmonary vascular resistance in the patient and thus treat pulmonary hypertension; and
removing the catheter from the pulmonary artery at the end of the procedure.
11. A method as in claim 10 , further comprising, before removing the catheter, changing the shape of the energy delivery portion from the second configuration to the first configuration.
12. A method as in claim 10 , wherein changing the shape of the energy delivery portion from the first configuration to the second configuration comprises inflating an inflatable balloon.
13. A method as in claim 10 , wherein changing the shape of the energy delivery portion from the first configuration to the second configuration comprises releasing a shape-memory portion of the catheter from a constraint to allow it to assume a default configuration.
14. A method as in claim 10 , wherein delivering energy from the energy delivery members comprises delivering a form of energy selected from the group consisting of radiofrequency, ultrasound, microwave, light, heat, cold, radiation, phototherapy, magnetic, electrical, electromagnetic, cryotherapy, plasma, mechanical, chemical, kinetic, potential, nuclear, elastic and hydrodynamic energy.
15. A method as in claim 10 , wherein, after the catheter is removed, no implant is left behind in the pulmonary artery.