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View Patent ↗A Cichorium intybus root hydrolyzate including oligofructosans and its use as active ingredient designed for use in a composition with cutaneous application, for acting as a substitute for vitamin D on skin cells, and for making it possible to preserve and/or to repair the cutaneous barrier function. Also cosmetic compositions including this active ingredient and to a cosmetic skin-care process.
1. A method of treating skin with a vitamin D deficiency, comprising topically applying an effective amount of an active ingredient to a subject in need thereof, said active ingredient being designed for use in a composition with cutaneous application, comprising a Cichorium intybus root hydrolyzate comprising oligofructosans.
2. The method according to claim 1 , wherein the effective amount of the active ingredient acts on skin cells similar to vitamin D.
3. The method according to claim 1 , wherein the effective amount of the active ingredient treats the skin by stimulating signaling paths regulated by vitamin D receptors in cutaneous cells.
4. The method according to claim 1 , wherein the effective amount of the active ingredient treats the skin by stimulating synthesis of vitamin D receptors and/or to increase functionality of the vitamin D receptor in cutaneous cells.
5. The method according to claim 1 , wherein the effective amount of the active ingredient treats the skin by stimulating network of genes engaged in terminal differentiation of keratinocytes.
6. The method according to claim 1 , wherein the effective amount of the active ingredient treats the skin by increasing expression of KLF4, cytokeratin 1, involucrin, cystatin E/M, and/or KLK5 in cutaneous cells.
7. The method according to claim 1 , wherein the effective amount of the active ingredient treats the skin by promoting formation of the epidermal barrier.
8. The method according to claim 2 , wherein the skin with the vitamin D deficiency is older, aged skin.
9. A method of preserving skin integrity or promoting recovery of skin barrier function, comprising topically applying to a subject in need thereof an effective amount of a composition for topical application, comprising an active ingredient designed for use in a composition with cutaneous application, comprising a Cichorium intybus root hydrolyzate comprising oligofructosans, the active ingredient being present between 0.01% and 3% by total weight of the composition.