Quinone based nitric oxide donating compounds
View Patent ↗The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
1. A method of treating Sickle cell disease comprising administering a compound of formula (I) to a patient in need thereof:
or steroisomers thereof, wherein
R 1 is selected from H, methyl, methoxy;
R 3 is selected from H, methyl, methoxy;
or R 1 and R 3 together form —CH═CH—CH═CH—;
R 2 is H, methyl;
n is an integer from 0 to 10;
Q is selected from the group consisting of:
wherein
m is an integer from 0 to 6;
p is an integer from 0 to 1;
X is O, S or is —CHONO 2 , with the proviso that when X is —CHONO 2 then m is 0.