IP Library Granted Patent US 9,079,821
Granted Patent B2
US 9,079,821 · App. 14/161,520 · Granted Jul 14, 2015

Quinone based nitric oxide donating compounds

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Quick Facts
Patent No.
US 9,079,821
App. No.
14/161,520
Granted
Jul 14, 2015
Kind
B2
Abstract

The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.

Claims (12)

1. A method of treating Sickle cell disease comprising administering a compound of formula (I) to a patient in need thereof:

or steroisomers thereof, wherein

R 1 is selected from H, methyl, methoxy;

R 3 is selected from H, methyl, methoxy;

or R 1 and R 3 together form —CH═CH—CH═CH—;

R 2 is H, methyl;

n is an integer from 0 to 10;

Q is selected from the group consisting of:

wherein

m is an integer from 0 to 6;

p is an integer from 0 to 1;

X is O, S or is —CHONO 2 , with the proviso that when X is —CHONO 2 then m is 0.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 5, 2018
From: NICOX SCIENCE IRELAND
To: NICOX SA
Reel/Frame 046789/0980 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 29, 2014
From: NICOX SA
To: NICOX SCIENCE IRELAND
Reel/Frame 033843/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 19, 2014
From: RONSIN, GAEL; STORONI, LAURA; BENEDINI, FRANCESCA
To: NICOX S.A.
Reel/Frame 032244/0006 →