Methods and compositions for wound healing
The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polyelectrolytes to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.
1. An article comprising: a polyelectrolyte multilayer formed from anionic and cationic polymers and being from 1 to 500 nm thick disposed on a support selected from the group consisting of a wound dressing and a biologic wound dressing, said polymer multilayer having a releasable antimicrobial silver composition incorporated therein, wherein said releasable antimicrobial silver composition is releasable in an amount of from 0.05 to 0.5 μg/cm 2 of said polymer multilayer per day.
2. A kit comprising the article of claim 1 .
3. The article of claim 1 , wherein said article is packaged in a sterile package.
4. The article of claim 1 , wherein said article does not substantially impair the healing of wounds.