Patch for treatment of eyelid disease containing clobetasol
A patch for treatment of eyelid diseases that is provided with a support, a pressure-sensitive adhesive layer, and a release layer in this order, wherein (a) the pressure-sensitive adhesive layer includes the following (a-1) to (a-4): (a-1) a styrene-isoprene-styrene block copolymer, a tackifier resin, and a softening agent are contained; (a-2) a ratio (mass ratio) of the styrene-isoprene-styrene block copolymer and the tackifier resin is 1:2 to 1:4; (a-3) a content of the softening agent is 40% to 60% by mass; and (a-4) further 0.005% to 5% by mass of clobetasol or acid ester thereof is contained; and (b) the support has elastic modulus with a Young's modulus of 0.01 to 0.5 GPa: and a method for producing the patch for treatment of eyelid diseases including: forming a pressure-sensitive adhesive layer on a upper surface of a release layer.
1. A patch for treatment of eyelid diseases, comprising a support, a pressure-sensitive adhesive layer, and a release layer in this order, wherein
(a-1) the pressure-sensitive adhesive layer includes a styrene-isoprene-styrene block copolymer, a tackifier resin, and a softening agent;
(a-2) a mass ratio of the styrene-isoprene-styrene block copolymer and the tackifier resin in the pressure-sensitive adhesive layer is 1:2 to 1:4;
(a-3) a content of the softening agent in the pressure-sensitive adhesive layer is 40% to 60% by mass; and
(a-4) the pressure-sensitive adhesive layer further comprises 0.005% to 5% by mass of clobetasol or acid ester thereof;
(b) the support has elastic modulus with a Young's modulus of 0.01 to 0.5 GPa;
(c) the styrene-isoprene-styrene block copolymer has a styrene content of 15% or more by mass and a diblock content of 30% or less by mass; and
(d) the support is a polyethylene film with a thickness of 1 to 80 μm.
2. The patch for treatment of eyelid diseases according to claim 1 , wherein
the mass ratio of the styrene-isoprene-styrene block copolymer and the tackifier resin is 1:2.4 to 1:3.5; and
the content of the softening agent is 40% to 55% by mass.
3. The patch for treatment of eyelid diseases according to claim 1 , wherein
the tackifier resin is a terpene resin.
4. The patch for treatment of eyelid diseases according to claim 1 , wherein
the softening agent is liquid at room temperature.
5. The patch for treatment of eyelid diseases according to claim 1 , wherein
the softening agent is liquid paraffin.
6. The patch for treatment of eyelid diseases according to claim 1 , wherein
a carrier film is provided on a surface of the opposite side of the pressure-sensitive adhesive layer side of the support.
7. The patch for treatment of eyelid diseases according to claim 6 , wherein
the carrier film is a polyester film.
8. The patch for treatment of eyelid diseases according to claim 6 , wherein
a surface of the support side of the carrier film is matt finished.
9. The patch for treatment of eyelid diseases according to claim 1 , wherein
an applying area per sheet is 0.5 to 10 cm 2 .
10. The patch for treatment of eyelid diseases according to claim 1 , wherein
the patch has a shape of a rectangle, an ellipse, a crescent, a circle, a horseshoe, or a ring.
11. The patch for treatment of eyelid diseases according to claim 1 , wherein
the patch provides an accumulated amount penetrated into the skin of clobetasol or acid ester thereof of 1.0 to 3.0 μg/cm 2 in 24 hours in an in vitro percutaneous permeability test using a hairless mouse skin.
12. A method for producing the patch for treatment of eyelid diseases according to claim 1 , comprising:
forming a pressure-sensitive adhesive layer on an upper surface of a release layer.
13. The patch for treatment of eyelid diseases according to claim 7 , wherein
a surface of the support side of the carrier film is matt finished.