IP Library › Granted Patent US 9,216,969
Granted Patent B2
US 9,216,969 · App. 13/871,364 · Granted Dec 22, 2015

Modulators of ATP-binding cassette transporters

Inventors: Sara S. Hadida Ruah (La Jolla, CA); Matthew Hamilton (Hackettstown, NJ); Mark Miller (San Diego, CA); Peter D. J. Grootenhuis (San Diego, CA); Brian Bear (Carlsbad, CA); Jason McCartney (Cardiff by the Sea, CA); Jinglan Zhou (San Diego, CA)
Assignee: Vertex Pharmaceuticals Incorporated
C07D405/12A61K31/443A61K31/444A61K31/4545A61K31/4709A61K31/496A61K31/497A61K31/501A61K31/506A61K31/5377A61K45/06C07D405/14
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Quick Facts
Patent No.
US 9,216,969
App. No.
13/871,364
Granted
Dec 22, 2015
Kind
B2
Abstract

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Claims (6)

1. A pharmaceutical composition comprising:

(i) a compound of the formula:

 and/or a pharmaceutically acceptable salt thereof;

(ii) a pharmaceutically acceptable carrier; and

(iii) a compound of the formula:

 and/or a pharmaceutically acceptable salt thereof.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Oct 14, 2016
From: MACQUARIE US TRADING LLC
To: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 040357/0001 →
ASSIGNEE CHANGE OF ADDRESS Recorded Feb 4, 2016
From: VERTEX PHARMACEUTICALS INCORPORATED
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 037697/0001 →
SECURITY INTEREST Recorded Jul 10, 2014
From: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
To: MACQUARIE US TRADING LLC
Reel/Frame 033292/0311 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 25, 2013
From: HADIDA RUAH, SARA; HAMILTON, MATTHEW; MILLER, MARK; GROOTENHUIS, PETER; BEAR, BRIAN; MCCARTNEY, JASON; ZHOU, JINGLAN; VAN GOOR, FREDRICK
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 031480/0973 →
Continuity (6)
Division 12114935 · May 5, 2008
Continuation PCTUS2006043289 · Nov 8, 2006
Provisional Application 60734506 · Nov 8, 2005
Provisional Application 60754086 · Dec 27, 2005
Provisional Application 60802458 · May 22, 2006
Related Publication 20130237569A1 · Sep 12, 2013