Sensor circuit for controlling, detecting, and measuring a molecular complex
A device for controlling, detecting, and measuring a molecular complex is disclosed. The device comprises a common electrode. The device further comprises a plurality of measurement cells. Each measurement cell includes a cell electrode and an integrator electronically coupled to the cell electrode. The integrator measures the current flowing between the common electrode and the cell electrode. The device further comprises a plurality of analog-to-digital converters, wherein an integrator from the plurality of measurement cells is electrically coupled to one analog-to-digital converter of the plurality of analog-to-digital converters.
1. An electric circuit for applying a voltage while simultaneously measuring a current flowing between the common electrode and the cell electrode, the electric circuit comprising:
a common electrode electrically to supply a common electric potential to an electrolyte in a liquid chamber;
a cell electrode electrically to supply a variable electric potential, wherein the voltage between the common electrode and the cell electrode equals the variable electric potential minus the constant liquid electric potential, and wherein the liquid chamber is positioned above the cell electrode; and
an integrator electronically coupled to the cell electrode, the integrator including an integrating capacitor, wherein a voltage across the integrating capacitor comprises a measure of the current flowing between the common electrode and the cell electrode during a measurement period, and the variable electric potential of the cell electrode is controlled by an applied voltage.
2. The electric circuit of claim 1 , wherein the integrator further includes an operational amplifier,
a first input of the operational amplifier is electrically coupled to a first terminal of the integrating capacitor and the cell electrode, the first input controls the variable electric potential of the cell electrode, and
the output of the operational amplifier is electrically coupled to a second terminal of the integrating capacitor and an input of a comparator.
3. The electric circuit of claim 1 , wherein the current flowing between the common electrode and the cell electrode flows in either direction depending on a controlling potential applied to a terminal of the integrator.
4. The electric circuit of claim 1 , wherein the variable electric potential of the cell electrode is controlled by the applied voltage via a buffering means.
5. The electric circuit of claim 1 , further comprising:
an analog-to-digital converter electrically coupled to the integrator.
6. The electric circuit of claim 5 , wherein the integrator further includes:
a buffering component, wherein the buffer component is electrically coupled to the analog-do-digital converter to buffer an output of the integrator before being connected to an analog-to-digital converter electrically coupled to the integrator.
7. The electric circuit of claim 1 , wherein the analog-to-digital converter measures a first voltage at an output of the integrator at a beginning of a measurement period and a second voltage at the output of the integrator at an end of the measurement period, and wherein a difference of the second voltage and the first voltage corresponds to a measurement of the current.
8. The electric circuit of claim 7 , wherein the measurement period is adjusted based at least in part on the current and how much time the current would take to cause a saturation.