IP Library Granted Patent US 9,302,238
Granted Patent B2
US 9,302,238 · App. 14/194,977 · Granted Apr 5, 2016

Nitric oxide generation, dilution, and topical application apparatus and method

Inventors: J. W. Randolph Miller (Orem, UT); John J. Miller (Orem, UT); Stephen H. Fairbanks (Orem, UT)
Assignee: SYK TECHNOLOGIES, LLC
B01J7/00A61K33/00
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Quick Facts
Patent No.
US 9,302,238
App. No.
14/194,977
Granted
Apr 5, 2016
Kind
B2
Abstract

An apparatus for controlled delivery of nitric oxide. A pump draws air through an activated carbon filter and into a reaction chamber. The generation of nitric oxide occurs in the reaction chamber. A second pump draws the gas in the reaction chamber through a calcium hydroxide filter and delivers the nitric oxide through an orifice, or aperture, that controls the flow of nitric oxide delivered. The nitric oxide is filtered through a calcium hydroxide filter just prior to being made available for various nitric oxide therapies. Topical applications that provide a nitric oxide therapy to a surface are also provided.

Claims (37)

1. A method of generating nitric oxide, the method comprising:

pumping a filtered gas into a reaction chamber, wherein the filtered gas is ambient air that has been filtered to remove oxygen and moisture;

providing a mixture of reactants in a solid form comprising at a mixture of a calcined chromium oxide compound in combination with, a nitrite compound and a nitrate compound in the reaction chamber;

activating the reactants to initiate a reaction generating a nitric oxide gas without the use of a liquid or a solution;

evacuating the nitric oxide gas away from the reaction chamber in a closed conduit to inhibit further heating thereof and to resist further reaction of the nitric oxide gas;

filtering the nitric oxide gas after the reaction; and

delivering the nitric oxide at substantially ambient conditions to a user to provide a therapeutically safe concentration of nitric oxide.

2. The method of claim 1 , wherein the reactants are activated by use of a heating element connected to the reaction chamber.

3. The method of claim 1 , further comprising:

cooling the nitric oxide gas after it is evacuated from the reaction chamber.

4. The method of claim 1 , further comprising:

analyzing the concentration of the nitric oxide gas being delivered to the user; and

adjusting the concentration of the nitric oxide gas being delivered to the user via an automated feedback loop to maintain a desired concentration.

5. A method for producing nitric oxide gas comprising:

pumping a filtered gas into a reaction chamber, wherein the filtered gas is ambient air that has been filtered to remove oxygen and moisture;

providing a granulated mixture of reactants, wherein the granulated mixture comprises effective amounts of calcined chromium oxide, a nitrite compound, and a nitrate compound and the granulated mixture is capable of passing through a five micron screen and capable of producing a nitric oxide gas in the reaction chamber, wherein the granulated mixture of reactants are activated by use of a heating element connected to the reaction chamber;

activating the reactants and generating the nitric oxide gas;

evacuating the nitric oxide gas away from the reaction chamber in a closed conduit to inhibit further heating thereof and to resist further reaction of the nitric oxide gas; and

delivering the nitric oxide at substantially ambient conditions to a user to provide a therapeutically safe concentration of nitric oxide.

6. The method of claim 5 , further comprising:

cooling the nitric oxide gas after it is evacuated from the reaction chamber.

7. The method of claim 6 , further comprising:

filtering the nitric oxide gas after it is evacuated from the reaction chamber.

8. The method of claim 6 , further comprising:

analyzing the concentration of the nitric oxide gas being delivered to the user; and

adjusting the concentration of the nitric oxide gas being delivered to the user via an automated feedback loop to maintain a desired concentration.

9. A method for producing nitric oxide gas comprising:

pumping a filtered gas into a reaction chamber;

providing a mixture of at least three reactants in the reaction chamber, wherein the mixture is in a solid form and comprises at least a calcined chromium oxide compound, a nitrite compound, and a nitrate compound;

activating the reactants and generating a nitric oxide gas;

evacuating the nitric oxide gas away from the reaction chamber in a closed conduit to inhibit further heating thereof and to resist further reaction of the nitric oxide gas;

cooling the nitric oxide gas;

filtering the nitric oxide gas;

analyzing the concentration of the nitric oxide gas;

adjusting the concentration of the nitric oxide gas; and

delivering the nitric oxide at substantially ambient conditions and at the adjusted concentration to a user.

10. The method of claim 9 , wherein the reactants are activated by use of a heating element connected to the reaction chamber.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 15, 2022
From: MILLER, J.W. RANDOLPH; MILLER, JOHN J.; FAIRBANKS, STEPHEN H.
To: GENOSYS, INC.
Reel/Frame 059015/0524 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 25, 2015
From: KIMBALL, SY
To: SYK TECHNOLOGIES, LLC
Reel/Frame 035909/0054 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 10, 2015
From: PATE BAIRD, PLLC
To: KIMBALL, SY
Reel/Frame 035128/0910 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 3, 2014
From: GENOSYS
To: PATE BAIRD, PLLC
Reel/Frame 033656/0596 →
Continuity (3)
Continuation 13197695 · Aug 3, 2011
Provisional Application 61370214 · Aug 3, 2010
Related Publication 20140314880A1 · Oct 23, 2014