Method for anti-aging treatment by surfactin in cosmetics via enhancing sirtuin
View Patent ↗Surfactin is a biosurfactant produced by Bacillus subtilis and is a natural cycloaliphatic peptide having a ring structure made of 7 amino acids. The surfactin has various functions including anti-aging, anti-wrinkle, increasing skin penetration of cosmetic products (skin penetration agent), foaming agent, and emulsifier.
1. A method for an anti-aging treatment comprising:
administering a cosmetic composition to a subject in need thereof, wherein the cosmetic composition comprises surfactin in a concentration between 25-100 μm, and pharmaceutically acceptable vehicles, excipients, diluents or adjuvants,
wherein the cosmetic composition performs an antiaging effect via enhancement of sirtuin.
2. The method as recited in claim 1 , wherein the surfactin is a cycloaliphatic peptide comprising a hepapeptide (L)Glu-(L)Leu-(D)Leu-(L)Val-(L)Asp-(D)Leu-(L)Leu linked to a β-hydroxy fatty acid, and the distribution of the fatty acids at the fatty acid end of the surfactin are as follows:
(1) iso-C13>3%;
(2) C13>0.65%;
(3) iso-C14>17%;
(4) C14<41%; and
(5) iso-C15<11%.
3. The method as recited in claim 2 , wherein the distribution of the fatty acids at the fatty acid end of the surfactin are as follows:
(1) iso-C13>10%;
(2) C13>25%;
(3) iso-C14>35%;
(4) C14<25%; and
(5) iso-C15<3%.
4. The method as recited in claim 3 , wherein the distribution of the fatty acids at the fatty acid end of the surfactin are as follows: (1) iso-C13=11%; (2) C13=26%; (3) iso-C14=37%; (4) C14=24%; and (5) iso-C15=2%.
5. The method as recited in claim 1 , wherein the molecular weight of the surfactin is 1022 or 1036 Da.
6. The method as recited in claim 1 , wherein the surfactin comprises its isomers.
7. The method as recited in claim 1 , wherein the anti-aging cosmetic composition further comprises at least one of the following ingredients: alcohols, esters, complex polysaccharides, nut oils, and vitamins.
8. The method as recited in claim 7 , wherein the alcohol comprises at least one of the following: C16-18 alcohols, butanediol, pentanediol, octanediol, glycerin, hexadecanol, stearyl alcohol, 1-Docosanol and propylene glycol.
9. The method as recited in claim 7 , wherein the esters comprise at least one of the following: OLIVEM 1000, glycerol monostearate (GSM), isopropyl myristate (IPM), isopropyl palmitate (IPP) and triglycerides.
10. The method as recited in claim 7 , wherein the complex polysaccharides comprise at least one of the following: xanthan gum, Tremella fuciforinis polysaccharides, dextran polysaccharides, and Folium sennae seed polysaccharides.
11. The method as recited in claim 7 , wherein the nut oil comprises at least one of the following: Argan oil, Kukui nut oil, avocado oil, wheat germ oil, and olive oil.
12. The method as recited in claim 7 , wherein the vitamins comprise at least one of the following: vitamin A, vitamin B, vitamin C, vitamin E, vitamin F, and vitamin K.
13. The method as recited in claim 1 , wherein the anti-aging cosmetic composition is used to promote fibroblast proliferation, collagen production or sertuin 1 gene expression.
14. The method as recited in claim 1 , wherein the anti-aging cosmetic composition is used to prevent photoaging induced by UV light or anti-oxidation.
15. The method as recited in claim 1 , wherein the anti-aging cosmetic composition is used to inhibit matrix metallopeptidase.
16. The method as recited in claim 15 , wherein the matrix metallopeptidase is matrix metallopeptidase 9.
17. The method as recited in claim 1 , wherein the cosmetic composition comprises surfactin in a concentration between 50-75 μm, and pharmaceutically acceptable vehicles, excipients, diluents, or adjuvants.