IP Library › Granted Patent US 9,428,849
Granted Patent B2
US 9,428,849 · App. 13/704,867 · Granted Aug 30, 2016

Polypeptide electrospun nanofibrils of defined composition

Inventors: Donald T. Haynie (Tampa, FL); Lei Zhai (Oviedo, FL)
Assignees: UNIVERSITY OF SOUTH FLORIDA; UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
D01F6/68C08G69/10D01D5/003D01D5/0007D04H1/728D04H3/016Y10T428/298
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Quick Facts
Patent No.
US 9,428,849
App. No.
13/704,867
Granted
Aug 30, 2016
Kind
B2
Abstract

Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.

Claims (6)

1. An electrospun nanofibril, comprising a polypeptide that is poly(L-glutamate, tyrosine), wherein the polypeptide satisfies the following equation: (non-polar surface area−polar surface area)/DP<100 square angstroms/residue, where DP is the degree of polymerization of the polypeptide.

2. The electrospun nanofibril according to claim 1 , wherein the polypeptide satisfies the opposite charges criterion.

3. The electrospun nanofibril according to claim 2 , wherein the degree of polymerization of the polypeptide is at least 25.

4. The electrospun nanofibril according to claim 1 , wherein a diameter of the nanofibril is less than a micron.

5. The electrospun nanofibril according to claim 2 , wherein a diameter of the nanofibril is less than a micron.

6. The electrospun nanofibril according to claim 3 , wherein a diameter of the nanofibril is less than a micron.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 20, 2013
From: UNIVERSITY OF SOUTH FLORIDA
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 030665/0587 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 11, 2013
From: HAYNIE, DONALD T.; ZHAI, LEI
To: UNIVERSITY OF SOUTH FLORIDA; UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
Reel/Frame 029610/0532 →
Continuity (2)
Provisional Application 61356955 · Jun 21, 2010
Related Publication 20130115457A1 · May 9, 2013