Membrane-type artificial scaffold and method for fabricating same
Provided herein are a membrane-type artificial scaffold for guided bone regeneration (GBR) and a method for fabricating the same. The membrane-type artificial scaffold according to the present invention comprises: a first layer made of at least one fiber layer arranged in parallel with each other with a first spacing therebetween such that the fiber layer contacts a bone tissue in vivo; and a second layer stacked on the first layer and made of at least one fiber layer arranged parallel to each other with a second spacing therebetween such that the fiber layer contacts a soft tissue in vivo. The first spacing is larger than the second spacing.
1. A membrane type scaffold comprising:
a first layer configured to be disposed to come into contact with bone tissue in a body and including first fibers arranged in parallel at first intervals and extending in a first direction; and
a second layer laminated on the first layer, configured to be disposed to come into contact with soft tissue in the body, and including second fibers arranged in parallel at second intervals and extending in a second direction crossing the first direction,
wherein the first interval is larger than the second interval,
wherein the first intervals are in a range of 150 μm to 400 μm, and the second intervals are in a range of 30 μm to 50 μm, and
wherein the first intervals are uniform with an error range within ±20 μm, and the second intervals are uniform with an error range within ±10 μm.
2. The membrane type scaffold of claim 1 , wherein:
heights of the first fibers and the second fibers are each in a range of 50 μm to 100 μm.
3. The membrane type scaffold of claim 1 , wherein:
the first fibers and the second fibers include polycaprolactone (PCL), and
the first fibers further include at least one of hydroxyapatite and tricalcium phosphate (TCP).
4. The membrane type scaffold of claim 3 , wherein:
the first fibers and the second fibers further include at least one of polylactic acid (PLA), polyglycolic acid (PGA), and polylactic-co-glycolic acid (PLGA) as an accessory component in addition to polycaprolactone (PCL).
5. The membrane type scaffold of claim 1 , wherein:
the first layer includes third fibers arranged at the first intervals and extending in a third direction, and fourth fibers fixed onto the third fibers, arranged at the first intervals, and extending in a fourth direction crossing the third direction, and
the second layer includes fifth fibers arranged at the second intervals and extending in a fifth direction, and sixth fibers fixed onto the fifth fibers, arranged at the second intervals, and extending in a sixth direction crossing the fifth direction.
6. The membrane type scaffold of claim 5 , wherein:
heights of the third fibers, the fourth fibers, the fifth fibers, and the sixth fibers are each in a range of 50 μm to 100 μm.
7. The membrane type scaffold of claim 5 , wherein:
the third fibers, the fourth fibers, the fifth fibers, and the sixth fibers include polycaprolactone (PCL), and
the third fibers and the fourth fibers further include at least one of hydroxyapatite and tricalcium phosphate (TCP).
8. The membrane type scaffold of claim 7 , wherein:
the third fibers, the fourth fibers, the fifth fibers, and the sixth fibers further include at least one of polylactic acid (PLA), polyglycolic acid (PGA), and polylactic-co-glycolic acid (PLGA) as an accessory component in addition to polycaprolactone (PCL).
9. A method of manufacturing a membrane type scaffold, comprising:
providing a first biopolymer and a second biopolymer to syringes of a first deposition head and a second deposition head, respectively;
spraying the first biopolymer through a nozzle of the first deposition head to form a first layer including first fibers arranged in parallel at first intervals and extending in a first direction; and
spraying the second biopolymer through a nozzle of the second deposition head on the first layer to form a second layer including second fibers arranged in parallel at second intervals and extending in a second direction crossing the first direction,
wherein the first interval and the second interval have different values,
wherein the first layer is configured to be disposed to come into contact with bone tissue in a body, the second layer is configured to be disposed to come into contact with soft tissue in the body, and
wherein the first interval is larger than the second interval,
wherein the first intervals are in a range of 150 μm to 400 μm, and the second intervals are in a range of 30 μm to 50 μm, and
wherein the first intervals are uniform with an error range within ±20 μm, and the second intervals are uniform with an error range within ±10 μm.
10. The method of claim 9 , wherein:
a height of at least one of the first layer and the second layer is in a range of 50 μm to 100 μm.
11. The method of claim 9 , wherein:
the first layer and the second layer include polycaprolactone (PCL), and
the first layer further includes at least one of hydroxyapatite and tricalcium phosphate (TCP).
12. The method of claim 11 , wherein:
the first layer and the second layer further include at least one of polylactic acid (PLA), polyglycolic acid (PGA), and polylactic-co-glycolic acid (PLGA) as an accessory component in addition to polycaprolactone (PCL).