Gel sheet containing lipid peptide gelator and polymeric compound
There is provided a gel sheet that has high biocompatibility and safety, can contain both a hydrophilic medicinal agent and a hydrophobic medicinal agent, and provides an excellent feel in use during the application onto human skin or others. A gel sheet including: a lipid peptide gelator including a low molecular weight lipid peptide having a molecular weight of 1,000 or less or a pharmaceutically usable salt of the lipid peptide; and a polymeric compound, wherein the polymeric compound is included in an amount of more than 1% (w/w) and less than 50% (w/w) with respect to the total mass of the gel sheet.
1. A gel sheet comprising:
a lipid peptide gelator including a low molecular weight lipid peptide having a molecular weight of 1,000 or less or a pharmaceutically usable salt of the lipid peptide; and
a polymeric compound, wherein:
the polymeric compound is included in an amount of more than 1% (w/w) and less than 50% (w/w) with respect to a total mass of the gel sheet; and
the low molecular weight lipid peptide is a lipid peptide of Formula (1) or a pharmaceutically usable salt of the lipid peptide:
where:
R 1 is a C 9-23 aliphatic group;
each of R 2 and R 3 is independently a hydrogen atom, a methyl group, an ethyl group, a C 3-7 alkyl group optionally having a C 1-3 branched chain, a phenylmethyl group, a phenylethyl group, or a —(CH 2 )n-X group;
at least one of R 2 and R 3 being a —(CH 2 )n-X group;
n is a number of 1 to 4;
X is an amino group, a guanidino group, a carbamoyl group, a 5-membered cyclic group or 6-membered cyclic group optionally having one to three nitrogen atoms, or a condensed heterocyclic group composed of a 5-membered ring and a 6-membered ring; and
m is 1.
2. The gel sheet according to claim 1 , wherein the polymeric compound is included in an amount of 2% (w/w) to 20% (w/w) with respect to the total mass of the gel sheet.
3. The gel sheet according to claim 1 , wherein the polymeric compound is selected from a linear polymeric compound having a hydroxy group and polysaccharides.
4. The gel sheet according to claim 3 , wherein the polymeric compound is polyvinyl alcohol, gum arabic, or gelatin.
5. The gel sheet according to claim 1 , wherein R 2 is a hydrogen atom, a methyl group, an i-propyl group, an i-butyl group, or a sec-butyl group.
6. The gel sheet according to claim 1 , wherein R 3 is a 4-aminobutyl group, 4-imidazolemethyl group, a carbamoylmethyl group, a 2-carbamoylethyl group, or a 3-indolemethyl group.
7. The gel sheet according to claim 1 , wherein R 1 is a C 13-17 aliphatic group, R 2 is a hydrogen atom, a methyl group, or an i-propyl group, and R 3 is a 4-aminobutyl group, a 4-imidazolemethyl group, or a 3-methylindole group.
8. The gel sheet according to claim 1 , wherein R 2 is a hydrogen atom and R 3 is a 4-imidazolemethyl group.
9. The gel sheet according to claim 1 , further comprising water, an alcohol, a polyhydric alcohol, a hydrophilic organic solvent, a hydrophobic organic solvent, or a mixed solution of two or more of these.
10. The gel sheet according to claim 9 , comprising water or a mixed solution of water and at least one selected from the group consisting of an alcohol, a polyhydric alcohol, an oil and fat, a silicone oil, and an ester solvent.
11. The gel sheet according to claim 10 , comprising water or a mixed solution of water and at least one selected from the group consisting of ethanol, 2-propanol, oleyl alcohol, phenoxy alcohol, glycerin, propylene glycol, polyethylene glycol, 1,3-butanediol, aqua jojoba oil, castor oil, olive oil, a silicone oil, and propylene glycol alginate.
12. The gel sheet according to claim 9 , comprising a polyhydric alcohol or a mixed solution of a polyhydric alcohol and at least one selected from the group consisting of an alcohol, an oil and fat, a silicone oil, and an ester solvent.
13. The gel sheet according to claim 12 , comprising at least one polyhydric alcohol selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, and 1,3-butanediol or a mixed solution of at least one of the polyhydric alcohols and at least one selected from the group consisting of ethanol, 2-propanol, oleyl alcohol, phenoxy alcohol, aqua jojoba oil, castor oil, olive oil, a silicone oil, and propylene glycol alginate.
14. The gel sheet according to claim 9 , comprising a solution containing water and one lactic acid salt selected from the group consisting of potassium lactate, sodium lactate, and calcium lactate.
15. The gel sheet according to claim 14 , further comprising at least one polyhydric alcohol selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, and 1,3-butylene glycol.
16. A laminate comprising:
the gel sheet according to claim 1 ; and
a support medium laminated on the sheet, the support medium including a nonwoven fabric, a film, or a foam.
17. The laminate according to claim 16 , further comprising a release film laminated on a surface on the opposite side of the gel sheet from the support medium.
18. The laminate according to claim 16 , wherein the support medium is selected from polyurethane, PVA, polypropylene, cellulose, and a laminated support medium of these.
19. The gel sheet according to claim 1 , wherein the gel sheet is a wound dressing sheet.
20. The gel sheet according to claim 1 , wherein the gel sheet is a skin protection sheet or a skin care sheet.
21. The laminate according to claim 16 , wherein the laminate is used for a wound dressing.
22. The laminate according to claim 16 , wherein the laminate is used for a skin protection sheet or a skin care sheet.