Fabrication of magnetic nanoparticles
Methods for forming core-shell magnetic nanoparticles are provided. The method can include: forming an oxide shell around a metal oxide core to form a core-shell magnetic nanoparticle; attaching an anchoring agent to the magnetic nanoparticle; reacting a RAFT agent with the functional group of the anchoring agent such that the RAFT agent is bonded to the magnetic nanoparticle through the anchoring agent; and attaching a polymeric chain to the RAFT agent.
1. A method of forming core-shell magnetic particles, the method comprising:
forming an oxide shell around a metal oxide core to form a core-shell magnetic particle, wherein the metal oxide core comprises an iron oxide;
attaching an anchoring agent to the magnetic particle, wherein the anchoring agent comprises a functional group;
reacting a reversible addition-fragmentation chain transfer (RAFT) agent with the functional group of the anchoring agent such that the RAFT agent is bonded to the magnetic particle through the anchoring agent; and
attaching a polymeric chain to the RAFT agent.
2. The method of claim 1 , further comprising:
non-covalently attaching an antimicrobial agent to the polymeric chain.
3. The method of claim 2 , further comprising:
exposing bacteria to the core-shell magnetic particle.
4. The method of claim 3 , further comprising:
recycling the core-shell magnetic particle.
5. The method of claim 1 , wherein attaching the polymeric chain to the RAFT agent comprises:
polymerizing a plurality of monomers on the RAFT agent to form a polymeric chain covalently bonded to the magnetic particle via the RAFT agent.
6. The method of claim 1 , wherein reacting a RAFT agent with the functional group of the anchoring agent such that the RAFT agent is bonded to the magnetic particle through the anchoring agent and attaching the polymeric chain to the RAFT agent comprises:
polymerizing a plurality of monomers to form the polymer chain with the RAFT agent attached; and
thereafter, attaching the polymeric chain to the particle surface via the RAFT agent.
7. The method as in claim 1 , wherein the oxide shell comprises silicon oxide.
8. The method as in claim 1 , wherein the oxide shell comprises silicon mixed with zirconium, titanium, or lanthanides.
9. The method as in claim 1 , wherein the metal oxide core comprises iron mixed with cobalt, manganese, titanium, zinc, tin, or a combination thereof.
10. The method as in claim 1 , wherein forming an oxide shell around a metal oxide core to form a magnetic nanoparticle comprises:
precipitating metal salts with a base to form the metal oxide core; and
hydrolyzation of tetraethyl orthosilicate on the metal oxide core to form an oxide shell on the metal oxide core, wherein the oxide shell comprises silicon oxide.
11. The method as in claim 10 , wherein the base comprises NH 4 OH, and wherein the metal salts comprise Fe(III) salts, Fe(II) salts, or a mixture thereof.
12. The method as in claim 11 , wherein the metal salts comprise a combination of Fe(III) salts and Fe(II) salts.
13. The method of claim 12 , wherein the molar ratio of Fe(III) salts to Fe(II) salts is about 4:1 to about 1:1.
14. The method of claim 12 , wherein the molar ratio of Fe(III) salts to Fe(II) salts is about 2:1.
15. The method as in claim 1 , wherein the average diameter of the magnetic particle prior to attaching the anchoring compound is about 1 nm to about 500 nm.
16. The method as in claim 1 , wherein the functional group of the anchoring agent comprises an amine functional group.
17. The method as in claim 1 , wherein the RAFT agent comprises 4-cyanopentanoic acid dithiobenzoate.