Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment of chronic inflammatory bowel disease, such as Crohn's disease and ulcerative colitis.
1. An antisense oligonucleotide against SMAD7 comprising SEQ ID NO: 9 (5′-YGCACXGAGTGXGTGAGZ-3′), wherein X is 5-methyl-2′-deoxycytidine 5′-monophosphate, Y is 2′-deoxyadenosine methylphosphonate, and Z is 2′-deoxycytidine methylphosphonate, or complements thereof.
2. A method of treating ulcerative colitis, comprising administering to a patient in need thereof an effective amount of the antisense oligonucleotide of claim 1 .
3. A method of treating inflammatory bowel disease, comprising administering to a patient in need thereof an effective amount of the antisense oligonucleotide of claim 1 .