IP Library Granted Patent US 9,522,085
Granted Patent B2
US 9,522,085 · App. 14/527,316 · Granted Dec 20, 2016

Methods, systems, and devices for treating tinnitus with VNS pairing

Inventors: Michael P. Kilgard (Richardson, TX); Navzer Engineer (Plano, TX); David Michael Pierce (Plano, TX)
Assignee: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
A61F11/00A61B5/128A61N1/361A61N1/36032A61N1/36053A61N1/36167A61N1/36171A61N1/36178A61N1/37235G09B23/28H04R25/75A61N1/0551A61N1/36092A61N1/36132A61N1/37247
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Quick Facts
Patent No.
US 9,522,085
App. No.
14/527,316
Granted
Dec 20, 2016
Kind
B2
Abstract

A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.

Claims (61)

1. A system, comprising:

a clinical controller providing therapy output signals including stimulation signals and sound signals;

stimulator communicably connected to the clinical controller and receiving stimulation signals from the clinical controller; and

headphones communicably connected to the clinical controller and receiving sound signals from the clinical controller,

wherein

the clinical controller provides a series of sound signals to the headphones and stimulation signals to the stimulator to relieve tinnitus symptoms, and

the series of sound signals are configured to cause the headphones to output a series of discrete therapeutic tones separated by a quiet period, the discrete therapeutic tones having a frequency other than a predetermined tinnitus frequency of a patient having the tinnitus symptoms.

2. The system of claim 1 , wherein the clinical controller provides a series of sound signals to the headphones and stimulation signals to the stimulator so that the series of sound signals are paired with stimulation signals to relieve the tinnitus symptoms.

3. The system of claim 1 , wherein the clinical controller provides a series of sound signals to the headphones and stimulation signals to the stimulator so that the series of sound signals are temporally linked with stimulation signals to relieve the tinnitus symptoms.

4. The system of claim 1 , wherein the clinical controller provides a series of sound signals to the headphones and stimulation signals to the stimulator so that the series of sound signals are temporally proximate to stimulation signals to relieve the tinnitus symptoms.

5. The system of claim 1 , wherein:

the clinical controller simultaneously provides a series of sound signals to the headphones and stimulation signals to stimulator to relieve tinnitus symptoms.

6. The system of claim 1 , wherein:

the clinical controller provides respective sound signals to the headphones before providing respective stimulation signals to the stimulator to relieve the tinnitus symptoms.

7. The system of claim 1 , wherein:

the clinical controller provides respective sound signals to the headphones after providing respective stimulation signals to the stimulator to relieve the tinnitus symptoms.

8. The system of claim 1 , wherein:

the discrete therapeutic tones are pure tones.

9. The system of claim 1 , wherein:

the stimulation signal is a stimulation control signal.

10. The system of claim 1 , wherein:

the stimulation signal is a stimulation voltage.

11. A system comprising:

tinnitus therapy software configured to cause the generation of stimulation ion signals and sound signals;

a stimulator controllable by the tinnitus therapy software and receiving stimulation signals; and

headphones controllable by the tinnitus therapy software and receiving sound signals;

wherein

the tinnitus therapy software is configured to cause the provision of a series of sound signals to the headphones and stimulation signals to the stimulator, and

the series of sound signals are configured to cause the headphones to output a series of discrete therapeutic tones separated b a quiet period, the discrete therapeutic tones having a frequency other than a predetermined tinnitus frequency of a patient having the tinnitus symptoms.

12. The system of claim 11 , wherein the tinnitus therapy software is configured to cause the provision of a series of sound signals to the headphones and stimulation signals to the stimulator so that the series of sound signals are paired with the stimulation signals.

13. The system of claim 11 , wherein the tinnitus therapy software is configured to cause the provision of a series of sound signals to the headphones and stimulation signals to the stimulator so that the series of sound signals are temporally linked to the stimulation signals.

14. The system of claim 11 , wherein the tinnitus therapy software is configured to cause the provision of a series of sound signals to the headphones and stimulation signals to the stimulator so that the series of sound signals are temporally proximate to the stimulation signals.

15. The system of claim 11 , wherein:

the tinnitus therapy software is configured to cause the provision of respective sound signals to the headphones before the provision of respective stimulation signals to the stimulator.

16. The system of claim 11 , wherein:

the tinnitus therapy software is configured to cause the provision of respective sound signals to the headphones after the provision of respective stimulation signals to the stimulator.

17. The system of claim 11 , wherein:

the tinnitus therapy software is configured to cause the provision of respective sound signals to the headphones while causing the provision of respective stimulation signals to the stimulator.

18. The system of claim 11 , wherein the tinnitus therapy software is configured to cause the provision of a series of sound signals to the headphones and stimulation signals to the stimulator so that the series of sound signals and the stimulation signals are synchronized.

19. The system of claim 11 , wherein:

the stimulation signal is a stimulation control signal.

20. The system of claim 11 , wherein:

the stimulation signal is a stimulation voltage.

21. A system comprising:

a clinical controller for providing therapy output signals including stimulation signals and sound signals;

a stimulator communicably connected to the clinical controller and receiving stimulation signals from the clinical controller; and

a sound generator communicably connected to the clinical controller and receiving sound signals from the clinical controller;

wherein

the clinical controller is configured to provide a plurality of sound signals to the sound generator and stimulation signals to the stimulator to relieve tinnitus symptoms, and

the clinical controller is configured to provide a plurality of sound signals such that the sound generator outputs respective therapeutic tones at least a half-octave above or below a predetermined tinnitus frequency of the patient having the tinnitus symptoms.

22. The system of claim 21 , wherein:

the clinical controller is configured to provide the plurality of sound signals such that the sound generator outputs the respective therapeutic tones at least a half-octave above a predetermined tinnitus frequency of the patient having the tinnitus symptoms.

23. The system of claim 21 , wherein:

the clinical controller is configured to provide the plurality of sound signals such that the sound generator outputs the respective therapeutic tones at least a half-octave below a predetermined tinnitus frequency of the patient having the tinnitus symptoms.

24. The system of claim 21 , wherein the clinical controller is configured to provide a plurality of sound signals to the sound generator and stimulation signals to the sound generator so that the series of sound signals are paired with stimulation signals to relieve the tinnitus symptoms.

25. The system of claim 21 , wherein the clinical controller is configured to provide a plurality of sound signals to the sound generator and stimulation signals to the sound generator so that the series of sound signals are temporally linked to stimulation signals to relieve the tinnitus symptoms.

26. The system of claim 21 , wherein the clinical controller is configured to provide a plurality of sound signals to the sound generator and stimulation signals to the sound generator so that the series of sound signals are temporally proximate to stimulation signals to relieve the tinnitus symptoms.

27. The system of claim 21 , wherein:

the stimulation signal is a stimulation control signal.

28. The system of claim 21 , wherein:

the stimulation signal is a stimulation voltage.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2021
From: ENGINEER, NAVZER D.; PIERCE, DAVID M.
To: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 057214/0991 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 2, 2016
From: MICROTRANSPONDER INC.
To: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 039315/0967 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 30, 2014
From: KILGARD, MICHAEL
To: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 034068/0223 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 30, 2014
From: ENGINEER, NAVZER; PIERCE, DAVID
To: MICROTRANSPONDER, INC.
Reel/Frame 034068/0287 →
Continuity (14)
Continuation 13934893 · Jul 3, 2013
Division 13673764 · Nov 9, 2012
Continuation In Part 13095570 · Apr 27, 2011
Continuation In Part 12485040 · Jun 15, 2009
Provisional Application 61699470 · Sep 11, 2012
Provisional Application 61614369 · Mar 22, 2012
Provisional Application 61598185 · Feb 13, 2012
Provisional Application 61558287 · Nov 10, 2011
Provisional Application 61328621 · Apr 27, 2010
Provisional Application 61077648 · Jul 2, 2008
Provisional Application 61078954 · Jul 8, 2008
Provisional Application 61086116 · Aug 4, 2008
Provisional Application 61149387 · Feb 3, 2009
Related Publication 20150051658A1 · Feb 19, 2015