Amylin and calcitonin receptor agonist
The present invention relates to peptides comprising an amino acid sequence SEQ ID NO: 1 (EASELSTAALGRLSAELHELATLPRTETGPESP), analogs and derivatives thereof and pharmaceutical compositions comprising such peptides and derivatives. This invention further regards the use of these peptides according to SEQ ID NO: 1, analogs and derivatives thereof as medicaments.
1. A peptide comprising the amino acid sequence of EASELSTAALGRLSAELHELATLPRTETGPESP (SEQ ID NO:1).
2. The peptide according to claim 1 , comprising a C-terminal amide group.
3. A derivative of the peptide according to claim 1 , wherein said derivative comprises a side chain covalently attached to the peptide at its N-terminal and wherein said side chain comprises fatty acid or fatty diacid.
4. The derivative according to claim 3 , wherein said fatty acid or fatty diacid comprises between 14 to 20 carbon atoms.
5. The derivative according to claim 3 , wherein said side chain further comprises a linker.
6. The derivative according to claim 5 , wherein said linker is selected from the group consisting of gGlu, gGlu-OEG, gGlu-OEG-OEG, gGlu-OEG-OEG-OEG, gGlu-OEG-OEG-OEG-OEG, and gGlu-OEG-OEG-OEG-OEG-OEG.
7. A derivative of the peptide according to claim 2 , wherein said derivative comprises a side chain covalently attached to the peptide at its N-terminal and wherein said side chain comprises fatty acid or fatty diacid.
8. The derivative according to claim 7 , wherein said fatty acid or fatty diacid comprises between 14 to 20 carbon atoms.
9. The derivative according to claim 7 , wherein said side chain further comprises a linker.
10. The derivative according to claim 9 , wherein said linker is selected from the group consisting of gGlu, gGlu-OEG, gGlu-OEG-OEG, gGlu-OEG-OEG-OEG, gGlu-OEG-OEG-OEG-OEG, and gGlu-OEG-OEG-OEG-OEG-OEG.
11. A compound which is
12. A pharmaceutical composition comprising the compound of claim 11 and a pharmaceutically acceptable excipient.
13. A method of reducing food intake comprising administering a pharmaceutically effective amount of the compound of claim 11 to a subject in need thereof.
14. A method of treating overweight comprising administering a pharmaceutically effective amount of the compound of claim 11 to a subject in need thereof.
15. A method of treating obesity comprising administering a pharmaceutically effective amount of the compound of claim 11 to a subject in need thereof.