Methods and systems for treating cardiovascular disease using an implantable electroacupuncture device
An exemplary method treating a cardiovascular disease in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to a median nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of T3 to T4, each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and the electroacupuncture device comprises a central electrode of a first polarity and an annular electrode of a second polarity and that is spaced apart from the central electrode; and 2) applying, by the electroacupuncture device, the stimulation sessions to the median nerve by way of the central electrode and the annular electrode in accordance with the duty cycle.
1. A method of treating a cardiovascular disease in a patient, comprising:
generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to a median nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein
each stimulation session included in the plurality of stimulation sessions comprises a series of stimulation pulses,
the duty cycle is a ratio of T3 to T4,
each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and
the electroacupuncture device comprises a central electrode of a first polarity centrally located on a first surface of a housing of the electroacupuncture device and an annular electrode of a second polarity and that is spaced apart from the central electrode; and
applying, by the electroacupuncture device, the stimulation sessions to the median nerve by way of the central electrode and the annular electrode in accordance with the duty cycle.
2. The method of claim 1 , wherein the stimulation sessions are configured to reduce sympathetic activity within the patient.
3. The method of claim 1 , wherein the cardiovascular disease comprises at least one of heart failure, coronary artery disease, myocardial ischemia, and angina.
4. The method of claim 1 , wherein the acupoint comprises PC6.
5. The method of claim 1 , wherein T3 is at least 10 minutes and less than 60 minutes, and wherein T4 is at least 1440 minutes.
6. The method of claim 1 , further comprising:
receiving, by the electroacupuncture device from a device external to the electroacupuncture device, a control command that sets the times T3 and T4 to appropriate values configured to treat the cardiovascular disease;
wherein the generating of the stimulation sessions is performed in accordance with the control command.
7. The method of claim 6 , wherein the receiving of the control command comprises detecting, with a magnetic field sensor included in the electroacupuncture device, a magnetic field generated by the device external to the electroacupuncture device.
8. The method of claim 1 , wherein the housing is coin-sized and coin-shaped.
9. The method of claim 1 , wherein the annular electrode is located on the first surface of the housing.
10. The method of claim 1 , wherein the annular electrode comprises a ring electrode located around a circumferential edge of the housing.
11. The method of claim 1 , wherein the applying of the stimulation sessions to the median nerve further comprises applying the stimulation sessions by way an electrode included on a lead connected to the electroacupuncture device.
12. The method of claim 1 , further comprising powering electronic circuits within the electroacupuncture device with a battery having an internal impedance of at least 5 ohms.
13. An electroacupuncture device for treating a cardiovascular disease in a patient, comprising:
a housing configured to be implanted beneath a skin surface of the patient at an acupoint corresponding to a median nerve of the patient;
a central electrode of a first polarity and centrally located on a first surface of the housing;
an annular electrode of a second polarity and that surrounds the central electrode on the first surface of the housing, the annular electrode being spaced apart from the central electrode; and
pulse generation circuitry located within the housing and electrically coupled to the annular and central electrodes and that
generates stimulation sessions configured to target the median nerve at a duty cycle that is less than 0.05, and
applies the stimulation sessions to the median nerve configured to target the median nerve by way of the central electrode and the annular electrode in accordance with the duty cycle,
such that
each stimulation session included in the plurality of stimulation sessions comprises a series of stimulation pulses,
the duty cycle is a ratio of T3 to T4, and
each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes.
14. The electroacupuncture device of claim 13 , wherein the stimulation sessions are configured to reduce sympathetic activity within the patient.
15. The electroacupuncture device of claim 13 , wherein the cardiovascular disease comprises at least one of heart failure, coronary artery disease, myocardial ischemia, and angina.
16. The electroacupuncture device of claim 13 , wherein the acupoint comprises PC6.
17. The electroacupuncture device of claim 13 , further comprising a magnetic field sensor that receives, from a device external to the electroacupuncture device, a control command that sets the times T3 and T4 to appropriate values configured to treat the cardiovascular disease.
18. The electroacupuncture device of claim 13 , further comprising a battery that powers the pulse generation circuitry, the battery having an internal impedance of at least 5 ohms.