Injectable osteogenic formula and method of using same
Formulations and methods for growing hone in a site specific location using an osteogenic molecule such as a prostaglandin, and a delivery vehicle which is preferably a polymer matrix.
1. A method of employing an osteogenic formulation to grow bone at a specific site in a mammal, comprising:
a) creating an osteogenic formulation by:
providing prostaglandin E1 (PGE1);
providing a gelatinous, water-soluble biodegradable 2 million Dalton poly-glutamic acid polymer matrix delivery vehicle for the PGE1;
mixing the PGE1 and the delivery vehicle; and
b) delivering the osteogenic formulation to the specific site in mammalian tissue such that the formulation makes contact with a bone surface so as to cause bone growth at the site, wherein both the matrix and the PGE1 are reabsorbed by the body.
2. The method of claim 1 in which delivery is accomplished with a syringe.
3. The method of claim 1 wherein the PGE1 is dissolved in water to create an osteogenic solution that is mixed with the delivery vehicle.
4. The method of claim 3 in which the mixing creates a homogeneous formulation.