Composition comprising oil palm phenolics for use in providing neuroprotective effects and cognitive-enhancement

1. A method for up-regulating at least one gene involved in neuroprotection in the brain of a subject in need thereof, the method comprising:

administering to said subject a composition comprising an effective amount of an extract from oil palm vegetation liquor, wherein said extract contains a mixture of phenolic compounds, fruit adds, fruit sugars and glycerol, wherein said extract contains an antioxidant content of about 1500 ppm gallic add equivalent;

wherein the amount of the composition administered is sufficient to up-regulate at least one gene involved in neuroprotection, wherein the gene is selected from the group consisting of Arc, Cast, Gria 3 , Kcnb 1 , Kcnab 1 , Homer 1 , Dlgap 2 , Dlgh 4 , Sv 2 b , Stx 1 a , Gucylb 3 , Ncald, Bzrap 1 , Pelo, Ptprn, Ptprt, Fas, Egr 1 , and Egr 4 ; and

wherein said composition is administered in the form of doses on a daily, weekly or monthly basis for a predetermined period of time, thereby providing neuroprotection in the brain of said subject.

2. The method of claim 1 , wherein the subject has at least one neurodegenerative disease or a disease related thereto.

3. The method of claim 1 , wherein the composition improves cognitive and motor functions in the subject.

4. The method of claim 1 , wherein the composition is administered in a dose dependent manner.

5. The method of claim 1 , wherein the composition is administered in a liquid dosage form.

6. The method of claim 1 , wherein the composition is administered in a pharmaceutically effective form.

7. The method of claim 1 , wherein the composition is administered in a nutraceutical form.

8. The method of claim 1 , wherein the composition is administered in a nutritional supplementary form.

9. The method of claim 1 , wherein the composition is administered in a suppository form.

10. The method of claim 1 , wherein the composition is administered in a form suitable for oral administration.

11. The method of claim 1 , wherein the composition is administered in a form suitable for intravenous administration.

12. A method of reducing inflammation in the brain of a patient having a neurodegenerative disease, the method comprising:

administering to said patient a composition comprising an effective amount of an extract from oil palm vegetation liquor, wherein said extract contains a mixture of phenolic, compounds, fruit adds, fruit sugars and glycerol, wherein said extract contains an antioxidant content of about 1500 ppm gallic add equivalent;

wherein at least one gene involved in acute phase response, aldehyde metabolism, hormone-mediated signaling, lipid metabolism, oxidoreductase activity, prostaglandin synthesis regulation, tumor necrosis factor-alpha/nuclear factor-kappaB (TNF-alpha/NF-kappaB) signaling, focal adhesion, and/or amino add metabolism is down-regulated; and

wherein said composition is administered in the form of doses on a daily, weekly or monthly basis for a predetermined period of time, thereby reducing inflammation in the brain of the patient.

13. The method of claim 12 , wherein the composition improves cognitive and motor functions in the patient.

14. The method of claim 12 , wherein the composition is administered in a dose dependent manner.

15. The method of claim 12 , wherein the composition is administered in a liquid dosage form.

16. The method of claim 12 , wherein the composition is administered in a pharmaceutically effective form.

17. The method of claim 12 , wherein the composition is administered in a nutraceutical form.

18. A method for up-regulating tyrosine phosphatase and/or ionotropic glutamate receptor genes, and/or down-regulating at least one gene from the group consisting actin, Hoxa 5 , and Hoxb 5 in the brain of a subject suffering from Alzheimer's Disease, the method comprising:

administering to said subject a composition comprising an effective amount of an extract from oil palm vegetation liquor, wherein said extract contains a mixture of phenolic compounds, fruit acids, fruit sugars and glycerol, wherein said extract contains an antioxidant content of about 1500 ppm gallic acid equivalent; and

wherein said composition is administered in the form of doses on a daily, weekly or monthly basis for a predetermined period of time, thereby up-regulating tyrosine phosphatase and/or ionotropic glutamate receptor genes, and/or down-regulating at least one gene from the group consisting actin, Hoxa 5 , and Hoxb 5 in the brain of said subject.