Device for determining the glucose level in body tissue
The apparatus for the non-invasive glucose detection comprises an electrical detection device ( 2 ) for measuring the response of the tissue or blood to an electric field at low frequencies below 1 MHz and at high frequencies above 10 MHz. The former is primarily dominated by skin hydration and sweat, while the latter contains contributions from the current glucose level. Combining the two signals allows an increased degree of accuracy. The apparatus further comprises a force or acceleration sensor ( 4, 5 ), which allows to detect the pressure of the apparatus against the skin and/or quick movements. Further sensor modules, such as a temperature sensor ( 6 ) or alternative perfusion sensor ( 7 ), improve the accuracy of the measured result.
1. An apparatus for determining a glucose level in body tissue or blood comprising
an electrical detection device having an electrode arrangement for applying an electric field to the tissue or blood for measuring at least one first parameter describing a response of said tissue or blood to said electric field,
an optical detection device comprising a light source and a light detector for measuring at least one second parameter describing a transmission or reflection of light by said tissue or blood, and
evaluation circuitry for determining the glucose level from a combination of said first and second parameter,
wherein the electrode arrangement comprises a plurality of parallel strip electrodes arranged to have gaps between each parallel strip electrode,
wherein said optical detection device is disposed behind the electrode arrangement such that the light source emits light through the gaps in said electrode arrangement and the light detector measures light transmitted through the gaps in said electrode arrangement for measuring said second parameter in a part of said tissue or blood experiencing said electric field.
2. The apparatus of claim 1 further comprising an AC voltage source for applying voltages of different frequencies to said electrode arrangement.
3. The apparatus of claim 1 wherein said optical detection device is adapted to determine said second parameter for at least a first and a second wavelength.
4. The apparatus of claim 3 wherein said first wavelength is in the visible spectrum.
5. The apparatus of claim 3 wherein said second wavelength is in the near infrared spectrum.
6. The apparatus of claim 1 wherein said optical detection device comprises a waveguide for transmitting incoming and/or outgoing light.
7. The apparatus of claim 6 wherein said electrode arrangement is planar and has a first surface for facing said body tissue or blood and a second opposite surface, wherein said waveguide is located at said second surface.
8. The apparatus of claim 1 further comprising a light emitting waveguide traversing the electrode arrangement and having surface gratings in the gaps between the electrode arrangement for decoupling light emitted from the light source and projecting said light onto said tissue or blood experiencing said electric field.
9. The apparatus of claim 1 further comprising a light detecting waveguide traversing the electrode arrangement and having surface gratings in the gaps between the electrode arrangement for coupling light reflected from said tissue or blood experiencing said electric field and projecting said reflected light onto the light detector.
10. The apparatus of claim 1 , wherein the structural arrangement of the electrical detection device with respect to the optical detection device enables measurements to be taken in a same physical volume of body tissue or blood.
11. An apparatus for determining a glucose level in body tissue or blood comprising
an electrical detection device having an electrode arrangement for applying an electric field to the tissue or blood for measuring at least one first parameter describing a response of said tissue or blood to said electric field,
an optical detection device comprising a light source and a light detector for measuring at least one second parameter describing a transmission or reflection of light by said tissue or blood, and
evaluation circuitry for determining the glucose level from a combination of said first and second parameter,
wherein the electrode arrangement comprises a plurality of electrodes arranged to have a plurality of parallel gaps between them,
wherein said optical detection device is disposed behind the electrode arrangement such that the light source emits light through the gaps in said electrode arrangement and the light detector measures light transmitted through the gaps in said electrode arrangement for measuring said second parameter in a part of said tissue or blood experiencing said electric field.
12. An apparatus for determining a glucose level in body tissue or blood comprising
an electrical detection device having an electrode arrangement for applying an electric field to the tissue or blood for measuring at least one first parameter describing a response of said tissue or blood to said electric field,
an optical detection device comprising a light source and a light detector for measuring at least one second parameter describing a transmission or reflection of light by said tissue or blood, and
evaluation circuitry for determining the glucose level from a combination of said first and second parameter,
wherein the electrode arrangement comprises a plurality of electrodes arranged in a plane to have a plurality of parallel gaps between them,
wherein said optical detection device is located at a distance from said plane of the electrode arrangement such that the light source emits light through the gaps in said electrode arrangement and the light detector measures light transmitted through the gaps in said electrode arrangement for measuring said second parameter in a part of said tissue or blood experiencing said electric field.