Circovirus sequences associated with piglet weight loss disease (PWD)
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
1. A method of inducing an immune response against porcine circovirus type B (PCVB), said method comprising administering one dose of a composition comprising a polypeptide encoded by a nucleic acid having at least 90% identity to SEQ ID NO:25 and a pharmaceutically or veterinarily acceptable carrier.
2. The method according to claim 1 , wherein said nucleic acid has at least 95% identity to SEQ ID NO:25.
3. The method according to claim 1 , wherein said nucleic acid has at least 98% identity to SEQ ID NO:25.
4. The method according to claim 1 , wherein said nucleic acid has 100% identity to SEQ ID NO:25.
5. A method of inducing an immune response against porcine circovirus type B (PCVB), said method comprising administering one dose of a composition comprising a polypeptide comprising an amino acid sequence having at least 90% identity to SEQ ID NO:26 and a pharmaceutically or veterinarily acceptable carrier.
6. The method according to claim 5 , wherein said amino acid has at least 95% identity to SEQ ID NO:26.
7. The method according to claim 5 , wherein said amino acid has at least 98% identity to SEQ ID NO:26.
8. The method according to claim 5 , wherein said amino acid has 100% identity to SEQ ID NO:26.