IP Library › Granted Patent US 9,751,918
Granted Patent B2
US 9,751,918 · App. 12/357,622 · Granted Sep 5, 2017

Transgenic plants expressing cobalamin binding proteins

Inventors: Lars Erik Berglund (Odder, DK); Torben Ellebaek Petersen (Skanderborg, DK); Sergey Nikolaevich Fedosov (Abyhoj, DK); Ebba Nexo (Abyhoj, DK); Niels Bech Laursen (Hojbjerg, DK); Erik Ostergaard Jensen (Abyhoj, DK)
Assignee: XERAGENX LLC
C07K14/47A61K31/7056A61K38/168A61K47/48107C07K14/415C12N5/0602C12N15/8257A61K38/00C12N2500/38
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Quick Facts
Patent No.
US 9,751,918
App. No.
12/357,622
Granted
Sep 5, 2017
Kind
B2
Abstract

The present invention relates to the use of transgenic plants for the expression of vitamin B12 (cobalamin) binding proteins. Plant cells are transformed with nucleotide sequences adapted for expression and secretion of vitamin B12 binding proteins. The present invention also relates to the use of recombinant vitamin B12 binding proteins from plants in analytical tests and treatment of vitamin B12 deficiency. Also disclosed is a method for purification of recombinant vitamin B12 binding proteins.

Claims (1)

1. A composition, the composition comprising intrinsic factor and a plant specific carbohydrate chain on the intrinsic factor, wherein all of the intrinsic factor is in the apo form.

Assignments (14)
SECURITY INTEREST Recorded Jul 24, 2026
From: ALBION LABORATORIES, INC.; BALCHEM CORPORATION
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 075393/0698 →
SECURITY INTEREST Recorded Apr 25, 2019
From: XERAGENX, LLC
To: BALCHEM CORPORATION
Reel/Frame 048998/0590 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 19, 2019
From: BENE CONSULTING, LLC; ATERES YESHUA, LLC
To: XERAGENX, LLC
Reel/Frame 048366/0382 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 1, 2012
From: BENE CONSULTING, L.C.; ATERES YESHUA, LLC
To: XERAGENX LLC
Reel/Frame 028315/0339 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 30, 2012
From: BENE CONSULTING, L.C.
To: ATERES YESHUA, LLC
Reel/Frame 028290/0659 →
RELEASE OF SECURITY INTEREST Recorded Mar 18, 2011
From: U.S. HEALTHCARE, LLC (AS ADMINISTRATIVE AND COLLATERAL AGENT)
To: DRUGTECH CORPORATION
Reel/Frame 025980/0024 →
RELEASE OF SECURITY INTEREST Recorded Mar 18, 2011
From: U.S. HEALTHCARE I, LLC (AS ADMINISTRATIVE AND COLLATERAL AGENT)
To: DRUGTECH CORPORATION
Reel/Frame 025981/0934 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NATURE OF CONVEYENCE PREVIOUSLY RECORDED ON REEL 025851 FRAME 0819. ASSIGNOR(S) HEREBY CONFIRMS THE CORRECT NATURE OF CONVEYENCE IS: RELEASE BY SECURED PARTY. Recorded Mar 16, 2011
From: U.S. HEALTHCARE I, L.L.C.
To: DRUGTECH CORPORATION
Reel/Frame 025959/0448 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 24, 2011
From: DRUGTECH CORPORATION
To: BENE CONSULTING L.C.
Reel/Frame 025855/0669 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 24, 2011
From: DRUGTECH CORPORATION
To: BENE CONSULTING L.C.
Reel/Frame 025855/0958 →
RELEASE OF SECURITY INTEREST Recorded Feb 22, 2011
From: U.S. HEALTHCARE I, L.L.C.
To: DRUGTECH CORPORATION
Reel/Frame 025843/0887 →
LIEN Recorded Feb 22, 2011
From: U.S. HEALTHCARE I, L.L.C.
To: DRUGTECH CORPORATION
Reel/Frame 025851/0819 →
PATENT SECURITY AGREEMENT Recorded Nov 20, 2010
From: DRUGTECH CORPORATION
To: U.S. HEALTHCARE I, LLC
Reel/Frame 025385/0498 →
PATENT SECURITY AGREEMENT Recorded Sep 14, 2010
From: DRUGTECH CORPORATION
To: U.S. HEALTHCARE I, L.L.C.
Reel/Frame 024982/0344 →
Priority Claims (1)
GB 0117171.9 · Jul 13, 2001 · national
Continuity (2)
Continuation 10483849
Related Publication 20100184642A1 · Jul 22, 2010