Anti-serum albumin binding variants
The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-14, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.
1. A nucleic acid comprising a nucleotide sequence encoding an anti-serum albumin immunoglobulin single variable domain comprising the amino acid sequence of SEQ ID NO: 412 (DOM7h-14-10 R108C).
2. A vector comprising the nucleic acid of claim 1 .
3. An isolated host cell comprising the vector of claim 2 .
4. A nucleic acid comprising a nucleic acid comprising a nucleotide sequence encoding an anti-serum albumin immunoglobulin single variable domain, said nucleic acid comprising the nucleotide sequence of SEQ ID NO: 413 (DOM7h-14-10 R108C).
5. A vector comprising the nucleic acid of claim 4 .
6. An isolated host cell comprising the vector of claim 5 .