Pharmaceutical compositions comprising polymeric binders with non-hydrolysable covalent bonds and their use in treating celiac disease
View Patent ↗A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.
1. Food comprising a pharmaceutically effective amount of a polymeric binder including a high molecular weight synthetic linear copolymer, the synthetic linear copolymer comprising a linear copolymer of hydroxyethyl methacrylate (HEMA) and 4-styrene sulfonic acid or a salt thereof, wherein said linear copolymer has a molar percentage ratio of HEMA:4-styrene sulfonic acid or a salt thereof from between about 82.4:17.6 mol % to about 28:72 mol %, and a processed food.
2. The food of claim 1 , wherein the food is a gluten-containing food.
3. The food of claim 2 , wherein the food is bread.
4. The food of claim 1 , wherein the synthetic linear copolymer comprises a copolymer of HEMA and SStNa hydrate.
5. The food of claim 4 , wherein the copolymer of HEMA and SStNa is linear HEMA/SStNa, wherein the HEMA/SStNa ratio is 51.5/48.5 mol %.
6. The food of claim 4 , wherein the copolymer of HEMA and SStNa is linear HEMA/SStNa, wherein the HEMA/SStNa ratio is 43/57 mol %.
7. The food of claim 4 , wherein the synthetic linear copolymer of HEMA and SStNa contains about 50% SStNa.
8. The food of claim 1 , wherein the synthetic linear copolymer has a backbone constituted of non-hydrolysable covalent bonds.
9. The food of claim 1 , wherein the synthetic linear copolymer is able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten.
10. The food of claim 1 , wherein the synthetic linear copolymer is able to form hydrophobic interactions with gluten or peptides derived from the degradation of gluten.
11. The food of claim 1 , wherein the synthetic linear copolymer is able to form hydrogen bonds.
12. The food of claim 1 , wherein the synthetic linear copolymer is able to specifically bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract.
13. The food of claim 1 , wherein the synthetic linear copolymer is able to bind to gluten or peptides derived from the degradation of gluten in the intestinal tract.