Electrospray ionizer for mass spectrometry of aerosol particles
A device and method are disclosed to apply ESI-based mass spectroscopy to submicrometer and nanometer scale aerosol particles. Unipolar ionization is utilized to charge the particles in order to collect them electrostatically on the tip of a tungsten rod. Subsequently, the species composing the collected particles are dissolved by making a liquid flow over the tungsten rod. This liquid with dissolved aerosol contents is formed into highly charged droplets, which release unfragmented ions for mass spectroscopy, such as time-of-flight mass spectroscopy. The device is configured to operate in a switching mode, wherein aerosol deposition occurs while solvent delivery is turned off and vice versa.
1. A system for electrospray ionization of species in aerosol particles, comprising:
a source for providing a sample of aerosol particles;
an aerosol deposition apparatus including:
a chamber for electrically charging the sample of aerosol particles; and
a nozzle for directing the sample of aerosol particles to an electrospray tip;
a solvent delivery mechanism for delivering a liquid to the electrospray tip; and
a high-voltage source for setting the electrospray tip at a high voltage, in order to enable the release of charged droplets carrying dissolved contents of the aerosol particles.
2. The system of claim 1 configured to operate in a switching mode, with the solvent delivery mechanism turned off while the aerosol deposition apparatus is on and vice versa.
3. The system of claim 2 , in which polarity of the high-voltage source has the capability of being switched between positive and negative polarities during periods of aerosol deposition being on and off.
4. The system of claim 1 , in which the electrospray tip includes a metal rod.
5. The system of claim 4 , wherein the nozzle is positioned for aerosol deposition to take place at the tip of the metal rod.
6. The system of claim 4 , wherein the nozzle is positioned for aerosol deposition to take place on the metal rod at a point distal from the tip of the rod.
7. The system of claim 6 , in which the metal rod is at least partially enclosed in a tube.
8. The system of claim 7 wherein the metal rod diameter is between 0.1 and 10 millimeters.
9. The system of claim 1 , and further comprising a mechanism configured to provide the ions that have been released from the charged droplets into a mass spectrometer.
10. A method for electrospray ionization of species in aerosol particles, comprising:
sampling aerosol particles from a gas flow;
applying an electrical charge to the sampled particles;
directing the sampled particles to an electrospray tip and allowing the particles to deposit on the electrospray tip;
delivering a solvent to the electrospray tip for removing the deposited particles from the electrospray tip; and
applying a high-voltage to the electrospray tip to release charged droplets carrying dissolved contents of the aerosol particles.
11. The method of claim 10 wherein the steps of allowing the particles to deposit on the electrospray tip and delivering the solvent are performed non-concurrently by operating in a switching mode such that when the particles are depositing on the tip, no liquid solvent is delivered and when liquid solvent is delivered to the tip no particles are being deposited.
12. The method of claim 11 , where the polarity of the high-voltage applied to the electrospray tip alternates polarities between a negative polarity applied during periods of aerosol deposition and a positive polarity applied during periods of solvent delivery.
13. The method of claim 10 , wherein the electrospray tip includes a metal rod.
14. The method of claim 13 , wherein aerosol deposition takes place at the tip of the metal rod.
15. The method of claim 13 , wherein aerosol deposition takes place on the metal rod at a point distal from the tip of the rod.
16. The method of claim 15 , wherein the metal rod is at least partially enclosed in a tube.
17. The method of claim 14 , wherein the metal rod has a diameter between 0.1 and 10 millimeters.