IP Library › Granted Patent US 9,834,607
Granted Patent B2
US 9,834,607 · App. 14/857,402 · Granted Dec 5, 2017

Bi-specific antibodies against Tim-3 and PD-1 for immunotherapy in chronic immune conditions

Inventors: Vijay K. Kuchroo (Newton, MA); Ana C. Anderson (Newton, MA)
Assignee: The Brigham and Women's Hospital, Inc.
C07K16/2803C07K16/28C07K16/2818C07K16/2896A61K2039/505A61K2039/507C07K2317/31C07K2317/73C07K2317/76
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Quick Facts
Patent No.
US 9,834,607
App. No.
14/857,402
Granted
Dec 5, 2017
Kind
B2
Abstract

Described herein are novel compositions comprising bispecific and multispecific polypeptide agents, and methods using these agents for targeting cells, such as functionally exhausted or unresponsive immune cells, that co-express the inhibitory receptors PD-1 and TIM-3. These compositions and methods are useful for the treatment of chronic immune conditions, such as persistent infections or cancer.

Claims (1)

1. A multispecific polypeptide agent comprising at least one binding site that specifically binds to a PD-1 molecule, and at least one binding site that specifically binds to a TIM-3 molecule.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2017
From: KUCHROO, VIJAY K.; ANDERSON, ANA C.
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 044025/0712 →
Continuity (4)
Continuation 13805030
Provisional Application 61356354 · Jun 18, 2010
Provisional Application 61365910 · Jul 20, 2010
Related Publication 20160002334A1 · Jan 7, 2016