Body fluid sampling arrangements
An arrangement for producing a sample of body fluid from an opening created in a skin surface at a sampling site including a cartridge with a plurality of compartments and a plurality of sampling sites, and a detector assembly. Each sampling site includes a skin-penetration member having a first end configured to pierce the surface of the skin and an inner lumen in communication with the first end, a spring actuator operatively associated with the skin-penetration member, and a needle hub connecting the skin-penetration member and the spring actuator. The needle hub includes a reagent pad and the spring actuator is configured to drive the skin-penetration member to form the wound opening. Each compartment at least partially encloses the skin-penetration member, the spring actuator, and the needle hub of a respective sampling site.
1. An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site, the arrangement comprising:
a cartridge comprising a plurality of compartments and a plurality of sampling sites, wherein each of the sampling sites comprises:
a skin-penetration member having a first end configured to pierce the surface of the skin, and an inner lumen in communication with the first end;
a spring actuator operatively associated with the skin-penetration member; and
a needle hub connecting the skin-penetration member and the spring actuator, wherein the needle hub comprises a reagent pad and wherein the spring actuator is configured to drive the skin-penetration member to form the wound opening,
wherein each of the compartments at least partially encloses the skin-penetration member, spring actuator, and needle hub of a respective sampling site of the plurality of sampling sites.
2. The arrangement of claim 1 , wherein the spring actuator drives the skin penetration member in an arcuate path.
3. The arrangement of claim 1 , further comprising at least one catalyst device comprising a means for applying vacuum pressure, positive pressure, or heat to the sampling site.
4. The arrangement of claim 3 , wherein the catalyst device comprises a pump, and wherein the pump is configured and arranged to apply a vacuum to the sampling site.
5. The arrangement of claim 4 , further comprising a controller operatively associated with the pump.
6. The arrangement of claim 1 , further comprising a housing, and wherein a footprint is disposed on the housing to be applied to the sampling site on the skin of a user.
7. The arrangement of claim 6 , wherein the footprint has an opening, and wherein the opening has a diameter of 3-8 mm.
8. The arrangement of claim 6 , wherein the footprint comprises an elastomeric seal.
9. The arrangement of claim 1 , wherein the skin-penetration member comprises a microneedle.
10. An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site, the arrangement comprising:
a cartridge comprising a plurality of compartments and a plurality of sampling sites, wherein each of the sampling sites comprises:
a skin-penetration member having a first end configured to pierce the surface of the skin;
a spring actuator operatively associated with the skin-penetration member; and
a needle hub connecting the skin-penetration member and the spring actuator, wherein the needle hub comprises a reagent pad and wherein the spring actuator is configured to drive the skin-penetration member to form the wound opening; and
a detector assembly in communication with the reagent pad of a sampling site,
wherein each of the compartments at least partially encloses the skin-penetration member, spring actuator, and needle hub of a respective sampling site of the plurality of sampling sites.
11. The arrangement of claim 10 , wherein the spring actuator drives the skin penetration member in an arcuate path.
12. The arrangement of claim 10 , further comprising at least one catalyst device comprising a means for applying vacuum pressure, positive pressure, or heat to the sampling site.
13. The arrangement of claim 12 , wherein the catalyst device comprises a pump, and wherein the pump is configured to apply a vacuum to the sampling site.
14. The arrangement of claim 13 , further comprising a controller operatively associated with the pump.
15. The arrangement of claim 10 , further comprising a housing, and wherein a footprint is disposed on the housing to be applied to the sampling site on the skin of a user.
16. The arrangement of claim 15 , wherein the footprint has an opening, and wherein the opening has a diameter of 3-8 mm.
17. The arrangement of claim 15 , wherein the footprint comprises an elastomeric seal.
18. The arrangement of claim 10 , wherein the detector assembly comprises at least one CMOS-based detector element.
19. The arrangement of claim 18 , wherein the detector assembly comprises a linear or area array of CMOS-based detector elements.
20. The arrangement of claim 10 , wherein the skin-penetration member comprises a microneedle.
21. An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site, the arrangement comprising:
a cartridge comprising a plurality of compartments and a plurality of sampling sites, wherein each of the sampling sites comprises:
a skin-penetration member having a first end configured to pierce the surface of the skin;
a spring actuator operatively associated with the skin-penetration member; and
a needle hub connecting the skin-penetration member and the spring actuator, wherein the needle hub comprises a reagent pad and wherein the spring actuator is configured to drive the skin-penetration member to form the wound opening,
wherein each of the compartments at least partially encloses the skin-penetration member, spring actuator, and needle hub of a respective sampling site of the plurality of sampling sites.
22. The arrangement of claim 21 , wherein the spring actuator drives the skin penetration member in an arcuate path.
23. The arrangement of claim 21 , further comprising at least one catalyst device comprising a means for applying vacuum pressure, positive pressure, or heat to the sampling site.
24. The arrangement of claim 23 , wherein the catalyst device comprises a pump, and wherein the pump is configured and arranged to apply a vacuum to the sampling site.
25. The arrangement of claim 24 , further comprising a controller operatively associated with the pump.
26. The arrangement of claim 21 , further comprising a housing, and wherein a footprint is disposed on the housing to be applied to the sampling site on the skin of a user.
27. The arrangement of claim 26 , wherein the footprint has an opening, and wherein the opening has a diameter or major dimension of 3-8 mm.
28. The arrangement of claim 26 , wherein the footprint comprises an elastomeric seal.
29. The arrangement of claim 21 , wherein the skin-penetration member comprises a microneedle.