Modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins capable of inducing broadly reactive T- and B-cell responses
The invention relates to HIV-1 envelope polypeptides comprising the consensus envelope of SEQ ID NO: 35, compositions comprising these envelopes and methods for using same.
1. A recombinant protein comprising the sequence of amino acids set forth in FIG. 29A (SEQ ID NO: 35).
2. A composition comprising the recombinant protein according to claim 1 and a carrier.
3. The recombinant protein according to claim 1 , wherein the sequence of said protein consists of SEQ ID NO: 35.
4. The composition of claim 2 , wherein the protein consists of SEQ ID NO: 35.
5. The composition of claim 2 or 4 further comprising an adjuvant.
6. A method of inducing an immune response in a mammal comprising administering to said mammal the composition of claim 2 , 4 or 5 in an amount sufficient to effect such induction.
7. A recombinant gp120 envelope protein derived from SEQ ID NO: 35, wherein the recombinant gp120 envelope protein comprises the consecutive amino acid sequence represented by amino acid numbers 30 to 484 of SEQ ID NO: 35.
8. The recombinant gp120 envelope protein of claim 7 , wherein the recombinant gp120 envelope protein consists of the consecutive amino acid sequence represented by amino acid numbers 30 to 484 of SEQ ID NO: 35.
9. A composition comprising the recombinant protein according to claim 7 or claim 8 and a carrier.
10. The composition of claim 9 further comprising an adjuvant.
11. A method of inducing an immune response in a mammal comprising administering to said mammal the composition of claim 9 or 10 in an amount sufficient to effect such induction.