Energy delivery systems and uses thereof
The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for delivering energy to difficult to access tissue regions (e.g. peripheral lung tissues), and/or reducing the amount of undesired heat given off during energy delivery.
1. A system comprising:
a) a primary catheter, wherein said primary catheter comprises a hollow primary lumen;
b) a channel catheter, wherein said channel catheter is concentrically positioned within said hollow primary lumen, and wherein said channel catheter comprises a channel lumen;
c) a steerable navigation catheter, wherein said steerable navigation catheter is configured to fit within said channel lumen, and wherein said steerable navigation catheter comprises a steerable tip and position sensing element; and
d) a microwave energy delivery device,
wherein said energy delivery device is configured to fit within said channel lumen,
wherein the microwave energy delivery device is of sufficient length to extend from the mouth of a human subject, through the trachea of the human subject, into the lung of the human subject and to the peripheral lung of the human subject,
wherein the diameter of the microwave energy delivery device is approximately 2 mm or less;
wherein the microwave energy delivery device is flexible;
wherein the microwave energy delivery device comprises an inner conductor, an outer conductor, and a stylet tip,
the inner conductor is a conductor of microwave energy,
the outer conductor is a conductor of microwave energy,
the inner conductor having a proximal end and a distal end,
the outer conductor having a proximal end and a distal end,
the stylet tip having a proximal end and a distal end,
the stylet tip attached at the distal end of the microwave energy delivery device;
wherein the microwave energy delivery device has therein one or more coolant channels for circulating and recirculating coolant, wherein the one or more coolant channels does not extend to the distal end of the stylet tip;
wherein the microwave energy delivery device has thereon a temperature sensor.
2. The system of claim 1 , wherein said primary catheter comprises a bronchoscope.
3. The system of claim 1 , wherein said microwave energy delivery device comprises a microwave ablation device.
4. The system of claim 1 , further comprising a handle for manipulation of one or more of said primary catheter, said channel catheter, said steerable navigation catheter, and said microwave energy delivery device.
5. The system of claim 1 , further comprising a processor configured to operate power delivery to said microwave energy delivery device.
6. The system of claim 1 , wherein said microwave energy delivery device is capable of delivering microwave energy through said channel catheter.
7. The system of claim 1 , wherein said channel catheter comprises a braided material that provides flexibility.
8. The system of claim 1 , further comprising a microwave power supply in electrical communication with said microwave energy delivery device.
9. A method of placing a microwave energy delivery device at a difficult to reach treatment site comprising:
a) providing the system of claim 1 , wherein said steerable navigation catheter is within the channel lumen, and said channel catheter is concentrically positioned within said hollow primary lumen;
b) inserting said primary catheter into an opening in a subject and directing said primary catheter towards said treatment site until further advance is constrained by the diameter of said primary catheter;
c) advancing said channel catheter beyond the distal end of said primary catheter and extending said channel catheter to said treatment site;
d) securing the distal end of said channel catheter at said treatment site;
e) withdrawing said steerable navigation catheter through said channel lumen and out the proximal end of said channel catheter;
f) inserting said microwave energy delivery device through said channel lumen until the distal end of said microwave energy delivery device reaches said treatment site.
10. The method of claim 9 , wherein said difficult to reach treatment site comprises the periphery of the lung.
11. The method of claim 10 , wherein said difficult to reach treatment site comprises a peripheral lung nodule.
12. The method of claim 11 , wherein said lung nodule is accessed through the bronchial tree.