Granted Patent B2

US 9,878,056 · App. 14/390,103 · Granted Jan 30, 2018

Inventors: Stephane Bancel (Cambridge, MA); Eric Yi-Chun Huang (Cambridge, MA)

Assignee: ModernaTX, Inc.

A61K48/0066A61K9/1271A61K9/145A61K9/5123A61K9/5146A61K9/5153A61K31/7115A61K38/17A61K38/177A61K38/1816A61K38/1891A61K38/191A61K38/193A61K38/212A61K38/45A61K38/4846A61K47/543A61K48/005A61K48/0033A61K48/0075C07K14/005C07K14/435C07K14/47C07K14/4705C07K14/4713C07K14/485C07K14/505C07K14/515C07K14/525C07K14/535C07K14/56C07K14/62C07K14/705C07K16/00C12N9/1051C12N9/16C12N9/2402C12N9/2445C12N9/644C12N9/6451C12N9/88C12N9/93C12N15/11C12N15/52C12N15/85C12N15/87C12P13/04C12P21/00C12P21/005C12Y603/02019A61K38/00C12Y304/21022

Abstract

Claims (9)

1. A cosmetic mRNA encoding SEQ ID NO: 1245, wherein said mRNA comprises a coding region, said coding region having at least 80% identity to SEQ ID NO: 1973.

2. The cosmetic mRNA of claim 1 , wherein the cosmetic mRNA comprises a poly-A tail.

3. The cosmetic mRNA of claim 1 , wherein the cosmetic mRNA comprises at least one 5′ terminal cap.

4. The cosmetic mRNA of claim 1 where the cosmetic mRNA is substantially purified.

5. The cosmetic mRNA of claim 1 , wherein the coding region is codon optimized.

6. The cosmetic mRNA of claim 1 , wherein the cosmetic mRNA comprises a 5′ untranslated region (UTR) at the 5′ terminus of the coding region and a 3′ UTR at the 3′ terminus of the coding region.

7. The cosmetic mRNA of claim 6 , wherein the 5′UTR and the 3′UTR are not derived from the same species.

8. The cosmetic mRNA of claim 6 , wherein at least one of the 5′UTR or the 3′UTR is not derived from beta-globin.

9. The cosmetic mRNA of claim 1 , wherein the coding region is selected from the group consisting of SEQ ID NO: 1973, 1974, 1987, 1976, 1975, 1986, 1978, 1981, 1977, 1985, 3423, 3437, 3428, 3436, 3424, 3431, 3425, 3427, and 4148.

Assignments (3)

Continuity (52)