IP Library Granted Patent US 9,951,003
Granted Patent B2
US 9,951,003 · App. 14/594,788 · Granted Apr 24, 2018

Isothiocyanate functional compound and associated method of use

Inventor: Michael E. Silver (Holland, MI)
Assignee: The William M. Yarbrough Foundation
C07C331/20A61K9/0014A61K31/145A61K31/198A61K31/26A61K45/06A61K47/34
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Quick Facts
Patent No.
US 9,951,003
App. No.
14/594,788
Granted
Apr 24, 2018
Kind
B2
Abstract

A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis, wherein said isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

Claims (14)

1. A method for treating phytophotodermatitis with an isothiocyanate functional surfactant, comprising the step(s) of:

applying a surfactant or a pharmaceutically acceptable salt thereof to skin affected by phytophotodermatitis, wherein the protonated form of said surfactant is represented by the following chemical structure:

wherein R 1 is selected from the group consisting of an alkyl group containing 1 to 25 carbon atom(s); wherein R 2 is selected from the group consisting of NCS; and wherein R 3 -R 5 are each independently selected from the group consisting of H; OH; and an alkyl, and alkanoyl group containing 1 to 25 carbon atom(s) with the proviso that at least one of R 3 -R 5 is selected from the group consisting of an alkyl, and alkanoyl, group containing 8 to 25 carbon atoms.

2. The method according to claim 1 , further comprising the step of applying a non-ionic surfactant.

3. The method according to claim 1 , further comprising the step of applying an anionic surfactant.

4. The method according to claim 1 , further comprising the step of applying a cationic surfactant.

5. The method according to claim 1 , further comprising the step of applying a zwitterionic surfactant.

6. A method for treating phytophotodermatitis with an isothiocyanate functional surfactant, comprising the step(s) of:

applying a surfactant or a pharmaceutically acceptable salt thereof to skin affected by phytophotodermatitis, wherein the surfactant is represented by the following chemical structure:

wherein R 1 is selected from the group consisting of an alkyl group containing 1 to 25 carbon atom(s); wherein R 2 is selected from the group consisting of NCS; and wherein R 3 -R 5 are each independently selected from the group consisting of H; OH; and an alkyl, and alkanoyl group containing 1 to 25 carbon atom(s) with the proviso that at least one of R 3 -R 5 is selected from the group consisting of an alkyl, and alkanoyl, group containing 8 to 25 carbon atoms; and wherein X comprises a counter cation.

7. The method according to claim 6 , further comprising the step of applying a non-ionic surfactant.

8. The method according to claim 6 , further comprising the step of applying an anionic surfactant.

9. The method according to claim 6 , further comprising the step of applying a cationic surfactant.

10. The method according to claim 6 , further comprising the step of applying a zwitterionic surfactant.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 3, 2017
From: SILVER, MICHAEL E.
To: THE WILLIAM M YARBROUGH FOUNDATION
Reel/Frame 041460/0695 →
Continuity (4)
Continuation 13342516 · Jan 3, 2012
Provisional Application 61429325 · Jan 3, 2011
Provisional Application 61502067 · Jun 28, 2011
Related Publication 20150126600A1 · May 7, 2015