Antisense oligonucleotides (ODN) against SMAD7 and uses thereof in medical field
The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment of chronic inflammatory bowel disease, such as Crohn's disease and ulcerative colitis.
1. An antisense oligonucleotide against Smad7 consisting of SEQ ID NO: 9 (5′-YGCACXGAGTGXGTGAGZ-3′), wherein X is 5-methyl-2′-deoxycytidine 5′-monophosphate, Y is 2′-deoxyadenosine methylphosphonate, and Z is 2′-deoxycytidine methylphosphonate, or a complement thereof.
2. A method of treating ulcerative colitis, the method comprising administering to a patient in need thereof an effective amount of the antisense oligonucleotide of claim 1 .
3. A method of treating inflammatory bowel disease, the method comprising administering to a patient in need thereof an effective amount of the antisense oligonucleotide of claim 1 .