IP Library Granted Patent US 9,994,552
Granted Patent B2
US 9,994,552 · App. 15/295,450 · Granted Jun 12, 2018

Compositions useful for treating disorders related to kit

Inventors: Lucian V. DiPietro (Gloucester, MA); Brian L. Hodous (Cambridge, MA); Joseph L. Kim (Wayland, MA); Chandrasekhar V. Miduturu (Cambridge, MA); Steven Mark Wenglowsky (Cambridge, MA); Douglas Wilson (Ayer, MA); Yulian Zhang (Acton, MA)
Assignee: BLUEPRINT MEDICINES CORPORATION
C07D403/14C07D239/94C07D401/12C07D401/14C07D403/04C07D403/12C07D405/14C07D409/14C07D413/14C07D473/34C07D487/04C07D487/08C07D487/22
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Quick Facts
Patent No.
US 9,994,552
App. No.
15/295,450
Granted
Jun 12, 2018
Kind
B2
Abstract

Compounds and compositions useful for treating disorders related to Kit are described herein.

Claims (11)

1. A compound selected from:

and pharmaceutically acceptable salts of any of the foregoing.

2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.

3. A method of treating mastocyctosis comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.

4. The method of claim 3 , wherein the mastocytosis is selected from cutaneous mastocytosis (CM) and systemic mastocytosis (SM).

5. The method of claim 4 , wherein the systemic mastocytosis is selected from indolent systemic mastocytosis (ISM), smoldering systemic mastocytosis (SSM), aggressive systemic mastocytosis (ASM), SM with associated hematologic non-mast cell lineage disease (SM-AHNMD), and mast cell leukemia (MCL).

6. A method of treating mastocyctosis comprising administering to a patient in need thereof a pharmaceutically effective amount of a pharmaceutical composition of claim 2 .

7. The method of claim 6 , wherein the mastocytosis is selected from cutaneous mastocytosis (CM) and systemic mastocytosis (SM).

8. The method of claim 7 , wherein the systemic mastocytosis is selected from indolent systemic mastocytosis (ISM), smoldering systemic mastocytosis (SSM), aggressive systemic mastocytosis (ASM), SM with associated hematologic non-mast cell lineage disease (SM-AHNMD), and mast cell leukemia (MCL).

9. A method of treating gastrointestinal stromal tumor, the method comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.

10. A method of treating gastrointestinal stromal tumor, the method comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition of claim 2 .

Assignments (4)
RELEASE OF SECURITY INTEREST (REEL/FRAME NUMBER 060616/0923) Recorded Jul 23, 2025
From: TAO TALENTS, LLC
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 072193/0847 →
SECURITY INTEREST Recorded Jul 8, 2022
From: BLUEPRINT MEDICINES CORPORATION
To: TAO TALENTS, LLC
Reel/Frame 060616/0923 →
ASSIGNEE CHANGE OF ADDRESS Recorded Jul 6, 2018
From: BLUEPRINT MEDICINES CORPORATION
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 046495/0375 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 3, 2017
From: DIPIETRO, LUCIAN V.; HODOUS, BRIAN L.; KIM, JOSEPH L.; MIDUTURU, CHANDRASEKHAR V.; WENGLOWSKY, STEVEN MARK; WILSON, DOUGLAS; ZHANG, YULIAN
To: BLUEPRINT MEDICINES CORPORATION
Reel/Frame 042224/0868 →
Continuity (3)
Continuation 14210526 · Mar 14, 2014
Provisional Application 61788857 · Mar 15, 2013
Related Publication 20170029409A1 · Feb 2, 2017