Photoactivatable crosslinker
View Patent ↗Described herein is a degradable linking agent of formula Photo 1 -LG-Photo 2 , wherein Photo 1 and Photo 2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
1. A linking agent comprising the formula:
wherein Photo 1 and Photo 2 , independently, represent a photoreactive group; n is an integer between 1 and 10; and R 1 -R 4 are independently cyclic, linear or branched, saturated or unsaturated, aromatic or heteroaromatic, a photoreactive group, hydroxyl or salt thereof, or a combination thereof.
2. The linking agent of claim 1 , wherein at least one heteroatom is selected from oxygen, nitrogen, sulfur, selenium or a combination thereof.
3. The linking agent of claim 1 , comprising a first photoreactive group attached to a first linking group by a first amine and a second photoreactive group attached to the first linking agent and the first photoreactive group by the first amine.
4. The linking agent of claim 3 , further comprising a third photoreactive group attached to the first linking group by a second amine.
5. The linking agent of claim 4 , further comprising a fourth photoreactive group attached to the first linking agent and the third photoreactive group by the second amine.
6. The linking agent of claim 1 , wherein one or more photoreactive groups comprise an aryl ketone.
7. The linking agent of claim 6 , wherein one or more photoreactive groups comprise benzophenone.
8. A method of coating a support surface with a linking agent in order to provide the surface with one or more latent reactive groups, the method comprising:
a) providing the support surface;
b) applying to the support surface the linking agent of claim 1 ; and
c) illuminating the linking agent upon the support surface under conditions suitable to activate a first photoreactive group to attach the linking agent to the surface, wherein a second photoreactive species remains unbound to the support surface and is able to revert to a latent reactive state.
9. A support surface bearing a coating comprising a polymer layer attached to the surface by the linking agent of claim 1 , wherein a first photoreactive group of the linking agent, when activated in the presence of the support surface, is able to attach the linking agent to the support surface, and a second photoreactive group of the linking agent, when activated in the presence of a coating agent, is able to attach the coating the surface.
10. A coated medical device comprising: a medical device and a polymeric coating, wherein the coating is attached to the medical device by the linking agent of claim 1 .
11. The linking agent of claim 1 , comprising the formula: